carbamazepine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
tricyclic compounds 489 298-46-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carbamazepine
  • carbamazepen
  • carbamazepin
  • carbazepine
  • carbamazepine dihydrate
  • carbamazepine hydrate
  • carbamazepine hydrochloride
  • carbamazepine sulfate
  • carbamazepine anhydrous
  • carbamazepine phosphate
  • carbamazepine tartrate
A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
  • Molecular weight: 236.27
  • Formula: C15H12N2O
  • CLOGP: 2.24
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 46.33
  • ALOGS: -3.19
  • ROTB: 0
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 g O
1 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.11 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 113.00 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 70 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
fu (Fraction unbound in plasma) 0.29 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

DateAgencyCompanyOrphan
March 11, 1968 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1358.07 10.78 1241 83606 131393 63272782
Drug reaction with eosinophilia and systemic symptoms 957.04 10.78 584 84263 33252 63370923
Toxicity to various agents 755.31 10.78 1255 83592 245995 63158180
Sedation 663.43 10.78 490 84357 38319 63365856
Cognitive disorder 642.87 10.78 559 84288 55256 63348919
Sedation complication 640.39 10.78 330 84517 13492 63390683
Creatinine renal clearance decreased 600.02 10.78 334 84513 15974 63388201
Balance disorder 573.13 10.78 633 84214 83789 63320386
Abortion spontaneous 572.56 10.78 487 84360 46708 63357467
Orthostatic hypotension 548.18 10.78 425 84422 35735 63368440
Depressed level of consciousness 533.31 10.78 528 84319 61550 63342625
Drug interaction 531.19 10.78 1032 83815 228099 63176076
Blood calcium decreased 495.27 10.78 353 84494 26098 63378077
Generalised tonic-clonic seizure 454.98 10.78 348 84499 28668 63375507
Epilepsy 447.38 10.78 335 84512 26730 63377445
Status epilepticus 387.66 10.78 246 84601 14987 63389188
Anticonvulsant drug level increased 371.80 10.78 120 84727 1397 63402778
Stevens-Johnson syndrome 368.85 10.78 289 84558 24661 63379514
Hyponatraemia 354.08 10.78 578 84269 111322 63292853
Psychotic disorder 290.75 10.78 255 84592 25457 63378718
Ataxia 277.97 10.78 200 84647 14995 63389180
Overdose 271.74 10.78 523 84324 114555 63289620
Joint swelling 257.50 10.78 61 84786 327605 63076570
Diarrhoea 236.83 10.78 370 84477 714996 62689179
Synovitis 233.89 10.78 3 84844 186915 63217260
Schizophrenia 231.70 10.78 152 84695 9800 63394375
Arthralgia 231.16 10.78 253 84594 569457 62834718
Rheumatoid arthritis 229.87 10.78 33 84814 253786 63150389
Infusion related reaction 229.29 10.78 29 84818 245492 63158683
Somnolence 228.72 10.78 638 84209 178047 63226128
Contraindicated product administered 226.04 10.78 17 84830 217631 63186544
Coma 223.41 10.78 347 84500 64017 63340158
Drug level increased 220.76 10.78 207 84640 22529 63381646
Petit mal epilepsy 218.34 10.78 105 84742 3689 63400486
Suicide attempt 215.04 10.78 331 84516 60587 63343588
Pemphigus 213.97 10.78 7 84840 183719 63220456
Nystagmus 203.43 10.78 118 84729 6102 63398073
Hand deformity 197.57 10.78 3 84844 159454 63244721
Jaundice cholestatic 195.65 10.78 122 84725 7202 63396973
Alopecia 195.20 10.78 104 84743 337432 63066743
Peripheral swelling 190.98 10.78 59 84788 265883 63138292
Diplopia 187.43 10.78 193 84654 23535 63380640
Dyspnoea 186.26 10.78 378 84469 660935 62743240
Swelling 185.72 10.78 68 84779 275310 63128865
Fall 182.54 10.78 1017 83830 391317 63012858
Exposure during pregnancy 182.12 10.78 538 84309 155009 63249166
Partial seizures 178.35 10.78 106 84741 5736 63398439
Abdominal discomfort 178.12 10.78 104 84743 320781 63083394
Stillbirth 171.69 10.78 109 84738 6641 63397534
Glossodynia 167.26 10.78 21 84826 178855 63225320
Arthropathy 165.15 10.78 54 84793 234738 63169437
Wound 163.27 10.78 15 84832 163248 63240927
Systemic lupus erythematosus 161.82 10.78 40 84807 208878 63195297
Fatigue 161.58 10.78 627 84220 887401 62516774
Focal dyscognitive seizures 156.54 10.78 77 84770 2844 63401331
Sinusitis 156.15 10.78 54 84793 226599 63177576
Intentional overdose 154.50 10.78 320 84527 73832 63330343
Drug eruption 150.95 10.78 189 84658 28505 63375670
Pericarditis 149.75 10.78 6 84841 131573 63272602
Drug intolerance 148.59 10.78 117 84730 308544 63095631
Gamma-glutamyltransferase increased 147.80 10.78 204 84643 33827 63370348
Aggression 146.94 10.78 169 84678 23329 63380846
Hypotension 136.24 10.78 721 84126 271883 63132292
Maternal exposure during pregnancy 135.64 10.78 618 84229 219444 63184731
Drug level decreased 135.22 10.78 100 84747 7819 63396356
Myoclonic epilepsy 135.22 10.78 54 84793 1200 63402975
Toxic epidermal necrolysis 135.07 10.78 168 84679 25166 63379009
Electroencephalogram abnormal 134.44 10.78 75 84772 3597 63400578
Inappropriate antidiuretic hormone secretion 131.67 10.78 131 84716 15331 63388844
Dysarthria 124.71 10.78 213 84634 42498 63361677
Discomfort 123.97 10.78 35 84812 167339 63236836
Trigeminal neuralgia 123.75 10.78 70 84777 3449 63400726
Altered state of consciousness 119.85 10.78 158 84689 25072 63379103
Multiple-drug resistance 118 10.78 78 84769 5092 63399083
Rash maculo-papular 117.73 10.78 177 84670 31719 63372456
Drug abuse 117.39 10.78 283 84564 72235 63331940
Loss of consciousness 116.41 10.78 385 84462 117736 63286439
Therapeutic product effect decreased 115.31 10.78 57 84790 193130 63211045
Anticonvulsant drug level above therapeutic 113.91 10.78 38 84809 494 63403681
Product use issue 113.30 10.78 78 84769 220442 63183733
Completed suicide 112.19 10.78 438 84409 145235 63258940
Mobility decreased 106.37 10.78 380 84467 120779 63283396
Sopor 104.04 10.78 138 84709 22026 63382149
Erythema multiforme 101.42 10.78 94 84753 10075 63394100
Hypersensitivity 100.64 10.78 147 84700 292538 63111637
Infection 100.33 10.78 95 84752 229078 63175097
Rheumatoid factor positive 98.99 10.78 3 84844 84403 63319772
Abortion induced 98.92 10.78 93 84754 10149 63394026
Treatment failure 97.54 10.78 74 84773 198969 63205206
Drug resistance 97.37 10.78 136 84711 22797 63381378
Febrile neutropenia 97.03 10.78 20 84827 118429 63285746
Helicobacter infection 96.96 10.78 7 84840 92778 63311397
Abnormal behaviour 95.38 10.78 130 84717 21296 63382879
Lymphocyte stimulation test positive 95.16 10.78 33 84814 486 63403689
Aura 91.26 10.78 39 84808 1034 63403141
Death 87.40 10.78 236 84611 374145 63030030
Intentional product use issue 87.11 10.78 31 84816 127861 63276314
Impaired healing 86.76 10.78 16 84831 102526 63301649
Product complaint 84.96 10.78 95 84752 12714 63391461
Anticonvulsant drug level below therapeutic 84.82 10.78 32 84815 607 63403568
Constipation 83.84 10.78 551 84296 224392 63179783
Psoriatic arthropathy 82.52 10.78 12 84835 91508 63312667
Hyperammonaemic encephalopathy 81.78 10.78 47 84800 2387 63401788
Speech disorder 80.70 10.78 172 84675 40457 63363718
Product substitution issue 80.37 10.78 103 84744 15893 63388282
Nasopharyngitis 78.59 10.78 137 84710 254120 63150055
Hepatic function abnormal 76.98 10.78 160 84687 36982 63367193
Musculoskeletal stiffness 76.79 10.78 80 84767 184538 63219637
Hepatotoxicity 76.11 10.78 159 84688 36882 63367293
Human herpes virus 6 serology positive 74.40 10.78 19 84828 86 63404089
Muscle injury 74.26 10.78 3 84844 65342 63338833
Hypotonia 74.17 10.78 76 84771 9209 63394966
Pain in extremity 72.88 10.78 215 84632 331271 63072904
Intellectual disability 71.55 10.78 33 84814 1053 63403122
Eosinophilia 71.10 10.78 117 84730 22639 63381536
Back pain 70.66 10.78 155 84692 263990 63140185
Cerebellar syndrome 70.30 10.78 49 84798 3490 63400685
Hyperammonaemia 69.61 10.78 57 84790 5175 63399000
Irritable bowel syndrome 69.41 10.78 13 84834 82399 63321776
Bradyphrenia 68.60 10.78 64 84783 6916 63397259
Lymphocyte morphology abnormal 68.47 10.78 25 84822 431 63403744
Dermatitis exfoliative 67.49 10.78 57 84790 5402 63398773
Anticonvulsant drug level decreased 67.08 10.78 33 84814 1219 63402956
Myoclonus 65.72 10.78 93 84754 15775 63388400
Sudden unexplained death in epilepsy 64.92 10.78 22 84825 301 63403874
Anaemia 64.71 10.78 190 84657 293240 63110935
Asthma-chronic obstructive pulmonary disease overlap syndrome 64.49 10.78 38 84809 2023 63402152
Blood bilirubin increased 63.39 10.78 148 84699 36992 63367183
Cholelithiasis 63.26 10.78 164 84683 43761 63360414
Dysmorphism 63.23 10.78 39 84808 2257 63401918
Psychogenic seizure 63.15 10.78 35 84812 1657 63402518
Oral mucosa erosion 62.84 10.78 31 84816 1152 63403023
Total lung capacity increased 60.49 10.78 38 84809 2272 63401903
Acute kidney injury 59.95 10.78 168 84679 263247 63140928
Arthritis 59.49 10.78 41 84806 115880 63288295
Multiple sclerosis relapse 58.85 10.78 170 84677 48308 63355867
Lip erosion 58.71 10.78 28 84819 965 63403210
General physical health deterioration 58.23 10.78 113 84734 201289 63202886
Neuroleptic malignant syndrome 58.02 10.78 76 84771 11980 63392195
Cross sensitivity reaction 57.71 10.78 36 84811 2126 63402049
Gastrointestinal disorder 56.69 10.78 55 84792 131184 63272991
Temporal lobe epilepsy 56.07 10.78 21 84826 390 63403785
Gastric lavage 55.59 10.78 13 84834 37 63404138
Tonic convulsion 54.44 10.78 29 84818 1268 63402907
Product dose omission issue 53.64 10.78 149 84698 234164 63170011
Injection site pain 53.11 10.78 57 84790 129743 63274432
Fibromyalgia 52.23 10.78 21 84826 80399 63323776
Vertigo 51.80 10.78 187 84660 59700 63344475
Oculomucocutaneous syndrome 51.71 10.78 15 84832 118 63404057
Hip arthroplasty 51.53 10.78 3 84844 47643 63356532
Neuropathy peripheral 51.02 10.78 46 84801 113621 63290554
Agitation 49.50 10.78 184 84663 59573 63344602
Behaviour disorder 49.30 10.78 38 84809 3161 63401014
Stomatitis 49.27 10.78 68 84779 138657 63265518
Off label use 49.08 10.78 622 84225 673840 62730335
Osteoarthritis 48.55 10.78 34 84813 95309 63308866
Histiocytosis 48.32 10.78 10 84837 12 63404163
Cough 48.30 10.78 214 84633 292529 63111646
Foetal anticonvulsant syndrome 48.21 10.78 21 84826 584 63403591
Intentional self-injury 47.87 10.78 106 84741 25581 63378594
Mucosal erosion 47.56 10.78 28 84819 1488 63402687
Irritability 47.36 10.78 120 84727 31574 63372601
Abdominal pain 46.93 10.78 217 84630 293239 63110936
Lower respiratory tract infection 46.84 10.78 65 84782 132242 63271933
Chest pain 46.74 10.78 141 84706 215818 63188357
Abdominal pain upper 46.70 10.78 132 84715 206312 63197863
Face oedema 46.56 10.78 91 84756 20121 63384054
Pyrexia 46.34 10.78 884 83963 469594 62934581
Nikolsky's sign 46.02 10.78 13 84834 92 63404083
Extrapyramidal disorder 45.19 10.78 71 84776 13213 63390962
Tremor 45.07 10.78 317 84530 131922 63272253
Suicidal ideation 45.03 10.78 184 84663 62237 63341938
Nausea 44.84 10.78 839 84008 853632 62550543
Meningomyelocele 44.57 10.78 20 84827 598 63403577
Pregnancy 44.54 10.78 129 84718 36707 63367468
Restlessness 44.51 10.78 112 84735 29341 63374834
Ovarian granulosa-theca cell tumour 43.99 10.78 10 84837 24 63404151
Malignant neoplasm progression 43.54 10.78 28 84819 82093 63322082
Ill-defined disorder 43.18 10.78 28 84819 81727 63322448
Human herpesvirus 6 infection 43.13 10.78 34 84813 2923 63401252
Asthma 42.87 10.78 65 84782 127496 63276679
Simple partial seizures 42.78 10.78 19 84828 554 63403621
Developmental glaucoma 42.68 10.78 11 84836 52 63404123
Aphasia 42.27 10.78 118 84729 32882 63371293
Lymphadenopathy 42.07 10.78 130 84717 38328 63365847
Headache 42.04 10.78 595 84252 632646 62771529
Mania 41.93 10.78 66 84781 12301 63391874
Coordination abnormal 41.93 10.78 70 84777 13703 63390472
Partial seizures with secondary generalisation 41.82 10.78 17 84830 396 63403779
COVID-19 41.63 10.78 54 84793 113049 63291126
Poisoning 40.87 10.78 69 84778 13631 63390544
Normal newborn 40.79 10.78 53 84794 8288 63395887
Psychomotor skills impaired 40.64 10.78 30 84817 2338 63401837
Maternal drugs affecting foetus 40.23 10.78 42 84805 5200 63398975
Adverse event 40.17 10.78 20 84827 67539 63336636
Angiofibroma 39.85 10.78 12 84835 109 63404066
Pain 39.50 10.78 725 84122 739903 62664272
Obsessive-compulsive disorder 39.46 10.78 37 84810 4023 63400152
Blood lactate dehydrogenase increased 39.31 10.78 92 84755 23024 63381151
Sarcoidosis 39.19 10.78 48 84799 7074 63397101
Hallucination, auditory 38.80 10.78 65 84782 12759 63391416
Spina bifida 38.31 10.78 20 84827 839 63403336
Hippocampal sclerosis 38.21 10.78 11 84836 84 63404091
Change in seizure presentation 38.06 10.78 16 84831 407 63403768
Central nervous system lesion 37.79 10.78 58 84789 10577 63393598
Atonic seizures 37.72 10.78 18 84829 621 63403554
Contusion 37.70 10.78 91 84756 149953 63254222
Cardiac failure congestive 37.35 10.78 41 84806 92392 63311783
Adverse drug reaction 37.30 10.78 31 84816 79683 63324492
Toxic skin eruption 37.25 10.78 64 84783 12821 63391354
Terminal insomnia 36.99 10.78 19 84828 770 63403405
Angiomyolipoma 36.44 10.78 13 84834 209 63403966
Bronchitis 36.17 10.78 70 84777 124865 63279310
Urinary incontinence 35.75 10.78 109 84738 31905 63372270
Injection site erythema 35.74 10.78 35 84812 83139 63321036
Mental disorder 35.51 10.78 95 84752 25824 63378351
Hepatocellular injury 35.16 10.78 98 84749 27283 63376892
Hyporeflexia 34.78 10.78 25 84822 1870 63402305
Mental impairment 34.17 10.78 65 84782 14086 63390089
Stereotypy 34.11 10.78 15 84832 427 63403748
Conversion disorder 34.05 10.78 24 84823 1740 63402435
Febrile convulsion 34.05 10.78 15 84832 429 63403746
Coma scale abnormal 33.80 10.78 38 84809 5115 63399060
Oscillopsia 33.77 10.78 11 84836 132 63404043
Psychomotor hyperactivity 33.54 10.78 55 84792 10608 63393567
Nephrogenic diabetes insipidus 33.51 10.78 19 84828 940 63403235
Blood cholesterol increased 33.47 10.78 46 84801 93986 63310189
Amyloid arthropathy 33.21 10.78 16 84831 564 63403611
Pregnancy with implant contraceptive 33.14 10.78 28 84819 2655 63401520
Bursitis 33.05 10.78 5 84842 37036 63367139
Blood alkaline phosphatase increased 32.86 10.78 129 84718 42838 63361337
Neurotoxicity 32.66 10.78 71 84776 16919 63387256
Blood creatine phosphokinase increased 32.48 10.78 102 84745 30328 63373847
Injection site pruritus 32.34 10.78 10 84837 45106 63359069
Blood sodium decreased 32.33 10.78 88 84759 24164 63380011
Loss of personal independence in daily activities 32.27 10.78 50 84797 97240 63306935
Hypertension 32.02 10.78 230 84617 279073 63125102
Disturbance in attention 31.97 10.78 118 84729 38071 63366104
Injection site swelling 31.58 10.78 12 84835 47560 63356615
Multiple drug therapy 31.24 10.78 31 84816 3615 63400560
Self esteem decreased 30.96 10.78 16 84831 657 63403518
Cerebral atrophy 30.93 10.78 36 84811 5030 63399145
Convulsive threshold lowered 30.62 10.78 13 84834 339 63403836
Dizziness 30.53 10.78 771 84076 429154 62975021
Nasal polyps 30.51 10.78 39 84808 6000 63398175
Pneumonia 30.31 10.78 429 84418 456338 62947837
Shock 30.15 10.78 84 84763 23379 63380796
Teratogenicity 30.12 10.78 12 84835 265 63403910
Multiple sclerosis 30.09 10.78 86 84761 24286 63379889
Bradycardia 30.08 10.78 184 84663 73043 63331132
Unintended pregnancy 29.81 10.78 39 84808 6140 63398035
Weight decreased 29.79 10.78 232 84615 276566 63127609
Hypogammaglobulinaemia 29.72 10.78 42 84805 7113 63397062
Disease progression 29.62 10.78 76 84771 122682 63281493
Diabetes insipidus 29.59 10.78 26 84821 2599 63401576
Bacteriuria 29.29 10.78 18 84829 1035 63403140
Musculoskeletal pain 29.13 10.78 49 84798 92228 63311947
Dyspepsia 28.94 10.78 58 84789 102138 63302037
Hospitalisation 28.92 10.78 43 84804 85038 63319137
Myocardial infarction 28.88 10.78 56 84791 99837 63304338
Delusion 28.78 10.78 55 84792 11962 63392213
Ophthalmoplegia 28.45 10.78 20 84827 1444 63402731
Eye movement disorder 28.39 10.78 35 84812 5193 63398982
Thinking abnormal 28.36 10.78 51 84796 10592 63393583
Atrial fibrillation 28.30 10.78 72 84775 116564 63287611
Gingival hypertrophy 28.30 10.78 21 84826 1650 63402525
Polydipsia 28.15 10.78 29 84818 3535 63400640
Caesarean section 28.11 10.78 67 84780 16965 63387210
Diverticulitis 27.94 10.78 9 84838 39548 63364627
Foetal exposure during pregnancy 27.80 10.78 100 84747 31862 63372313
Conjunctival hyperaemia 27.70 10.78 24 84823 2355 63401820
Gastrointestinal haemorrhage 27.62 10.78 41 84806 81135 63323040
Facial pain 27.37 10.78 50 84797 10511 63393664
Hypervolaemia 27.36 10.78 3 84844 28410 63375765
Fulminant type 1 diabetes mellitus 26.89 10.78 13 84834 462 63403713
Lymphangioleiomyomatosis 26.89 10.78 10 84837 182 63403993
Epileptic psychosis 26.84 10.78 7 84840 35 63404140
Psychiatric symptom 26.82 10.78 34 84813 5189 63398986
Psoriasis 26.69 10.78 47 84800 86910 63317265
Gaze palsy 26.67 10.78 19 84828 1401 63402774
Drug withdrawal convulsions 26.61 10.78 19 84828 1406 63402769
Mood altered 26.53 10.78 60 84787 14683 63389492
Colitis 26.48 10.78 16 84831 48512 63355663
Device expulsion 26.40 10.78 7 84840 34915 63369260
Persecutory delusion 26.30 10.78 25 84822 2765 63401410
Paradoxical drug reaction 26.18 10.78 30 84817 4122 63400053
Urinary tract infection 26.13 10.78 227 84620 264457 63139718
Injection site reaction 25.88 10.78 24 84823 58500 63345675
Areflexia 25.77 10.78 26 84821 3092 63401083
SUNCT syndrome 25.75 10.78 5 84842 3 63404172
Joint stiffness 25.49 10.78 12 84835 41857 63362318
Joint range of motion decreased 25.48 10.78 6 84841 32422 63371753
Stupor 25.47 10.78 30 84817 4245 63399930
Bipolar disorder 24.96 10.78 41 84806 7919 63396256
Right ventricular dilatation 24.90 10.78 18 84829 1358 63402817
Osteonecrosis of jaw 24.79 10.78 8 84839 35115 63369060
Fluid retention 24.64 10.78 26 84821 59660 63344515
Neuromyelitis optica spectrum disorder 24.57 10.78 16 84831 1018 63403157
Disorientation 24.38 10.78 111 84736 39341 63364834
Intra-abdominal pressure increased 24.36 10.78 10 84837 239 63403936
Catatonia 24.35 10.78 30 84817 4447 63399728
Influenza 24.21 10.78 70 84777 108652 63295523
Memory impairment 24.16 10.78 229 84618 104029 63300146
Blood hyposmosis 24.09 10.78 6 84841 24 63404151
Genital erosion 24.09 10.78 9 84838 166 63404009
Illusion 24.07 10.78 16 84831 1054 63403121
Cardiac arrest 23.85 10.78 208 84639 92337 63311838
Dyskinesia 23.60 10.78 95 84752 31907 63372268
Pseudolymphoma 23.44 10.78 13 84834 616 63403559
Ammonia increased 23.42 10.78 30 84817 4626 63399549
Pulmonary pain 23.34 10.78 26 84821 3464 63400711
Gait disturbance 23.33 10.78 359 84488 182819 63221356
Petechiae 23.29 10.78 55 84792 13842 63390333
Polydipsia psychogenic 23.20 10.78 7 84840 64 63404111
Epileptic aura 23.01 10.78 7 84840 66 63404109
Mitochondrial enzyme deficiency 23.00 10.78 6 84841 30 63404145
Erythema 22.98 10.78 346 84501 175405 63228770
Chest discomfort 22.92 10.78 73 84774 109896 63294279
Vaccination site reaction 22.87 10.78 8 84839 121 63404054
Epidermolysis bullosa 22.81 10.78 8 84839 122 63404053
Respiratory arrest 22.57 10.78 95 84752 32550 63371625
Learning disorder 22.41 10.78 13 84834 672 63403503
Sciatica 22.22 10.78 9 84838 34315 63369860
Ear malformation 22.01 10.78 9 84838 213 63403962
Skin erosion 21.99 10.78 22 84825 2590 63401585
Mydriasis 21.89 10.78 49 84798 11907 63392268
Deafness congenital 21.71 10.78 5 84842 13 63404162
Disorganised speech 21.65 10.78 16 84831 1249 63402926
Anaemia megaloblastic 21.57 10.78 11 84836 439 63403736
Pleural effusion 21.50 10.78 59 84788 93151 63311024
Eosinophil count increased 21.39 10.78 46 84801 10882 63393293
Immune thrombocytopenia 21.31 10.78 45 84802 10511 63393664
Encapsulating peritoneal sclerosis 21.09 10.78 10 84837 340 63403835
Slow speech 21.06 10.78 17 84830 1512 63402663
Ultrasound ovary abnormal 21.05 10.78 7 84840 90 63404085
Seizure cluster 21.05 10.78 9 84838 239 63403936
Hepatitis 21.01 10.78 107 84740 39681 63364494
Antipsychotic drug level decreased 21.01 10.78 10 84837 343 63403832
Abortion 20.97 10.78 21 84826 2475 63401700
Hyperthermia 20.82 10.78 41 84806 9115 63395060
Clostridium difficile infection 20.80 10.78 7 84840 29915 63374260
Euphoric mood 20.77 10.78 29 84818 4858 63399317
Apathy 20.75 10.78 40 84807 8754 63395421
Dysphagia 20.74 10.78 195 84652 88390 63315785
Palpitations 20.71 10.78 79 84768 112691 63291484
Single umbilical artery 20.57 10.78 9 84838 253 63403922
Respiratory depression 20.56 10.78 52 84795 13663 63390512
Oxygen saturation decreased 20.49 10.78 56 84791 88529 63315646
Productive cough 20.47 10.78 33 84814 63175 63341000
Dexamethasone suppression test positive 20.24 10.78 4 84843 3 63404172
Macular degeneration 20.19 10.78 4 84843 24372 63379803
Sepsis 20.10 10.78 121 84726 153002 63251173
Amnesia 19.95 10.78 135 84712 55450 63348725
Knee arthroplasty 19.81 10.78 26 84821 54180 63349995
Alanine aminotransferase increased 19.78 10.78 219 84628 103551 63300624
Benzodiazepine drug level increased 19.78 10.78 8 84839 184 63403991
Affective disorder 19.74 10.78 32 84815 6114 63398061
Congenital spinal fusion 19.71 10.78 4 84843 4 63404171
Pyuria 19.68 10.78 18 84829 1896 63402279
Chronic kidney disease 19.62 10.78 19 84828 45379 63358796
Cardiac murmur 19.59 10.78 53 84794 14499 63389676
Lethargy 19.49 10.78 135 84712 55872 63348303
Hypomagnesaemia 19.49 10.78 7 84840 28730 63375445
Toxic encephalopathy 19.44 10.78 33 84814 6546 63397629
Cranial nerve disorder 19.41 10.78 11 84836 544 63403631
Sinus arrest 19.40 10.78 18 84829 1931 63402244
Developmental delay 19.40 10.78 16 84831 1467 63402708
Cleft lip 19.37 10.78 7 84840 117 63404058
Dystonia 19.28 10.78 51 84796 13768 63390407
Liver injury 19.22 10.78 32 84815 60488 63343687
Lymphocytosis 19.17 10.78 21 84826 2746 63401429
Bone pain 19.17 10.78 27 84820 54614 63349561
Abortion threatened 19.10 10.78 11 84836 561 63403614
Dyspnoea exertional 19.05 10.78 32 84815 60270 63343905
Inflammation 19.03 10.78 52 84795 82221 63321954
Pneumatosis 19.03 10.78 10 84837 425 63403750
Developmental regression 18.85 10.78 5 84842 27 63404148
Cellulitis 18.81 10.78 52 84795 81906 63322269
Blood osmolarity decreased 18.79 10.78 13 84834 915 63403260
Peripheral nerve decompression 18.70 10.78 5 84842 28 63404147
Microcephaly 18.64 10.78 13 84834 927 63403248
Hypoproteinaemia 18.63 10.78 18 84829 2031 63402144
Skin ulcer 18.62 10.78 18 84829 43027 63361148
Encephalocele 18.45 10.78 7 84840 135 63404040
Therapeutic response unexpected 18.32 10.78 61 84786 18698 63385477
Labelled drug-drug interaction medication error 18.24 10.78 49 84798 13350 63390825
Blood pressure fluctuation 18.21 10.78 21 84826 46296 63357879
Dry mouth 18.17 10.78 49 84798 77814 63326361
Upper respiratory tract infection 18.14 10.78 53 84794 81994 63322181
Conjunctivitis 18.03 10.78 65 84782 20731 63383444
Psychomotor retardation 18.01 10.78 24 84823 3846 63400329
Sensorimotor disorder 17.99 10.78 10 84837 476 63403699
Acinetobacter test positive 17.99 10.78 6 84841 78 63404097
Full blood count abnormal 17.95 10.78 10 84837 31707 63372468
Purpura 17.94 10.78 44 84803 11341 63392834
Medulloblastoma 17.87 10.78 5 84842 34 63404141
Septic shock 17.86 10.78 39 84808 66590 63337585
Mucosal inflammation 17.68 10.78 22 84825 46906 63357269
Pleural neoplasm 17.59 10.78 9 84838 362 63403813
Haemoglobin decreased 17.54 10.78 118 84729 145367 63258808
Product dispensing error 17.51 10.78 41 84806 10264 63393911
Dementia 17.37 10.78 60 84787 18734 63385441
Confusional state 17.35 10.78 426 84421 235954 63168221
Pneumonitis 17.35 10.78 13 84834 35209 63368966
Carbohydrate antigen 15-3 17.26 10.78 6 84841 89 63404086
Neoplasm progression 17.24 10.78 14 84833 36414 63367761
Neurosis 17.21 10.78 8 84839 260 63403915
Lactate pyruvate ratio increased 17.20 10.78 6 84841 90 63404085
Muscle spasms 17.19 10.78 130 84717 156020 63248155
Acid base balance abnormal 17.18 10.78 8 84839 261 63403914
Autism spectrum disorder 17.17 10.78 12 84835 858 63403317
Atrioventricular block 17.09 10.78 34 84813 7613 63396562
Carcinoembryonic antigen 17.08 10.78 6 84841 92 63404083
Interstitial granulomatous dermatitis 17.05 10.78 5 84842 41 63404134
Eyelid oedema 17.05 10.78 41 84806 10438 63393737
Accidental overdose 17.03 10.78 69 84778 23240 63380935
Rhesus incompatibility 16.96 10.78 6 84841 94 63404081
Lennox-Gastaut syndrome 16.96 10.78 8 84839 269 63403906
Urticaria vesiculosa 16.95 10.78 4 84843 12 63404163
Brain lobectomy 16.86 10.78 3 84844 0 63404175
Lymphocyte transformation test positive 16.86 10.78 3 84844 0 63404175
Tensilon test abnormal 16.86 10.78 3 84844 0 63404175
Therapeutic product effective for unapproved indication 16.84 10.78 6 84841 96 63404079
Drug level above therapeutic 16.78 10.78 26 84821 4779 63399396
Pulmonary valve stenosis congenital 16.76 10.78 7 84840 175 63404000
Wound infection 16.75 10.78 4 84843 21406 63382769
Pulmonary hypertension 16.68 10.78 15 84832 37108 63367067
Lymphopenia 16.50 10.78 58 84789 18269 63385906
Hyperphosphatasaemia 16.48 10.78 4 84843 14 63404161
Rectal haemorrhage 16.45 10.78 25 84822 49005 63355170
Epileptic encephalopathy 16.43 10.78 8 84839 289 63403886
Osteomalacia 16.42 10.78 11 84836 734 63403441
Enanthema 16.42 10.78 9 84838 417 63403758
Ideas of reference 16.40 10.78 6 84841 104 63404071
Injection site haemorrhage 16.36 10.78 6 84841 24308 63379867
Hyperacusis 16.34 10.78 17 84830 2096 63402079
Obsessive thoughts 16.18 10.78 10 84837 581 63403594
Red blood cell sedimentation rate increased 16.17 10.78 21 84826 43961 63360214
Epistaxis 16.06 10.78 47 84800 72678 63331497
Asterixis 16.06 10.78 14 84833 1385 63402790
Wrong drug 16.03 10.78 7 84840 196 63403979
Joint injury 15.78 10.78 10 84837 29562 63374613
Syncope 15.69 10.78 232 84615 117153 63287022
Herpes zoster 15.64 10.78 57 84790 82405 63321770
Cholestasis 15.43 10.78 79 84768 29355 63374820
Blood citric acid increased 15.43 10.78 5 84842 59 63404116
Injection site bruising 15.42 10.78 20 84827 41890 63362285
Cardiac failure 15.38 10.78 64 84783 89078 63315097
Brain injury 15.37 10.78 31 84816 7012 63397163
Derailment 15.35 10.78 5 84842 60 63404115
Tearfulness 15.31 10.78 23 84824 4116 63400059
Therapeutic product ineffective for unapproved indication 15.30 10.78 7 84840 219 63403956
Pupillary disorder 15.30 10.78 7 84840 219 63403956
Depressed mood 15.26 10.78 99 84748 40092 63364083
Myalgia 15.19 10.78 124 84723 146405 63257770
Hepatitis A 15.19 10.78 9 84838 484 63403691
Aspartate aminotransferase increased 15.19 10.78 186 84661 90091 63314084
Paranoia 15.19 10.78 42 84805 11637 63392538
Persistent depressive disorder 15.16 10.78 12 84835 1038 63403137
Hyperkalaemia 15.14 10.78 31 84816 54172 63350003
Rhinitis allergic 15.08 10.78 42 84805 11685 63392490
Hallucination 15.07 10.78 125 84722 54692 63349483
Metapneumovirus infection 15.06 10.78 12 84835 1048 63403127
Type 2 diabetes mellitus 15.05 10.78 40 84807 63828 63340347
Necrosis ischaemic 15.00 10.78 11 84836 849 63403326
Speech disorder developmental 14.89 10.78 10 84837 670 63403505
Nervous system disorder 14.88 10.78 57 84790 18709 63385466
Urinary tract malformation 14.78 10.78 3 84844 3 63404172
Fabry's disease 14.78 10.78 3 84844 3 63404172
Juvenile myoclonic epilepsy 14.73 10.78 4 84843 24 63404151
Epilepsy surgery 14.73 10.78 4 84843 24 63404151
Lung disorder 14.67 10.78 39 84808 62222 63341953
Haematochezia 14.64 10.78 31 84816 53513 63350662
Oral mucosal eruption 14.56 10.78 10 84837 695 63403480
Rash morbilliform 14.53 10.78 20 84827 3305 63400870
Periodic limb movement disorder 14.52 10.78 7 84840 247 63403928
Pulmonary mass 14.51 10.78 6 84841 22590 63381585
Decreased appetite 14.50 10.78 242 84605 250810 63153365
Night sweats 14.43 10.78 27 84820 48787 63355388
Brugada syndrome 14.41 10.78 8 84839 380 63403795
Anaphylactic reaction 14.39 10.78 43 84804 66057 63338118
Congenital megaureter 14.33 10.78 5 84842 75 63404100
Injury 14.31 10.78 50 84797 73197 63330978
Vitamin D deficiency 14.31 10.78 46 84801 13846 63390329
Developmental hip dysplasia 14.30 10.78 13 84834 1359 63402816
Skin test positive 14.22 10.78 10 84837 722 63403453
Vanishing bile duct syndrome 14.22 10.78 10 84837 722 63403453
Basal cell carcinoma 14.22 10.78 10 84837 27981 63376194
Pseudophaeochromocytoma 14.21 10.78 5 84842 77 63404098
Vaginal erosion 14.20 10.78 4 84843 28 63404147
Thrombosis 14.19 10.78 42 84805 64713 63339462
Odynophagia 14.07 10.78 31 84816 7455 63396720
Trigeminal nerve disorder 14.04 10.78 6 84841 159 63404016
Cerebellar atrophy 14.03 10.78 10 84837 738 63403437
Congenital cystic kidney disease 14.02 10.78 8 84839 401 63403774
Hypothermia 14.01 10.78 45 84802 13536 63390639
Hypomania 13.98 10.78 28 84819 6302 63397873
Near drowning 13.96 10.78 4 84843 30 63404145
Hepatitis fulminant 13.90 10.78 20 84827 3444 63400731
Thyroid adenoma 13.84 10.78 6 84841 165 63404010
Hyperlactacidaemia 13.77 10.78 18 84829 2831 63401344
Infrapatellar fat pad inflammation 13.77 10.78 6 84841 167 63404008
Hypoglycaemia neonatal 13.77 10.78 11 84836 964 63403211
Paralogism 13.73 10.78 4 84843 32 63404143
Hypometabolism 13.73 10.78 4 84843 32 63404143
Pharyngeal erythema 13.68 10.78 14 84833 1694 63402481
Blood immunoglobulin M decreased 13.64 10.78 11 84836 977 63403198
Genital burning sensation 13.60 10.78 7 84840 285 63403890
Enlarged foetal cisterna magna 13.57 10.78 3 84844 6 63404169
Papule 13.57 10.78 26 84821 5665 63398510
Vaginal ulceration 13.54 10.78 8 84839 428 63403747
Photophobia 13.53 10.78 53 84794 17582 63386593
Hyperprolactinaemia 13.48 10.78 21 84826 3879 63400296
Drug-induced liver injury 13.44 10.78 96 84751 40126 63364049
Blood pressure increased 13.43 10.78 145 84702 161917 63242258
Tooth development disorder 13.41 10.78 4 84843 35 63404140
Procedural pain 13.41 10.78 6 84841 21563 63382612
Quadriparesis 13.37 10.78 15 84832 2014 63402161
Pigmentation disorder 13.36 10.78 23 84824 4616 63399559
Skin exfoliation 13.33 10.78 101 84746 43001 63361174
Anal erosion 13.31 10.78 4 84843 36 63404139
Candida infection 13.29 10.78 11 84836 28340 63375835
Acquired diaphragmatic eventration 13.27 10.78 8 84839 444 63403731
Hypercalcaemia 13.26 10.78 11 84836 28311 63375864
Aortic bypass 13.26 10.78 3 84844 7 63404168
Hyperglycinaemia 13.26 10.78 3 84844 7 63404168
Fungal infection 13.16 10.78 18 84829 36856 63367319
Skin lesion 13.12 10.78 78 84769 30643 63373532
Dry skin 13.12 10.78 36 84811 56851 63347324
Postictal state 13.12 10.78 11 84836 1032 63403143
Respiratory tract infection 13.11 10.78 22 84825 41461 63362714
Sinus congestion 13.02 10.78 4 84843 18119 63386056
Carnitine decreased 12.97 10.78 3 84844 8 63404167
Pulmonary arterial hypertension 12.95 10.78 7 84840 22570 63381605
Agranulocytosis 12.86 10.78 67 84780 25067 63379108
Trance 12.85 10.78 4 84843 41 63404134
Nodule 12.84 10.78 6 84841 21020 63383155
Poverty of speech 12.83 10.78 7 84840 321 63403854
Disseminated intravascular coagulation 12.83 10.78 55 84792 18996 63385179
Wheezing 12.82 10.78 75 84772 95520 63308655
Conjunctival discolouration 12.78 10.78 5 84842 105 63404070
Arnold-Chiari malformation 12.73 10.78 9 84838 656 63403519
Angiosclerosis 12.71 10.78 3 84844 9 63404166
Norovirus infection 12.67 10.78 9 84838 661 63403514
Anticoagulation drug level decreased 12.52 10.78 4 84843 45 63404130
Cataract 12.50 10.78 37 84810 57016 63347159
Dehydration 12.48 10.78 160 84687 173194 63230981
Therapy interrupted 12.45 10.78 15 84832 32440 63371735
Incoherent 12.44 10.78 22 84825 4508 63399667
Altered visual depth perception 12.43 10.78 7 84840 342 63403833
Colitis ulcerative 12.38 10.78 10 84837 26081 63378094
Cerebellar ataxia 12.36 10.78 10 84837 892 63403283
Drug dependence 12.34 10.78 65 84782 24418 63379757
Facial spasm 12.32 10.78 9 84838 690 63403485
Full blood count decreased 12.32 10.78 10 84837 26014 63378161
Drug level changed 12.31 10.78 6 84841 217 63403958
Drug tolerance decreased 12.30 10.78 4 84843 17469 63386706
Lymphocytic infiltration 12.29 10.78 10 84837 900 63403275
Selective IgG subclass deficiency 12.25 10.78 3 84844 11 63404164
Acantholysis 12.25 10.78 3 84844 11 63404164
Thrombocytopenic purpura 12.24 10.78 12 84835 1379 63402796
Encephalopathy 12.23 10.78 91 84756 38529 63365646
Neonatal seizure 12.21 10.78 8 84839 514 63403661
Kidney duplex 12.13 10.78 4 84843 50 63404125
Negative thoughts 12.12 10.78 10 84837 917 63403258
Papillary thyroid cancer 12.08 10.78 15 84832 2241 63401934
Hepatitis acute 12.06 10.78 33 84814 9087 63395088
Pulmonary venous thrombosis 12.05 10.78 3 84844 12 63404163
Frequent bowel movements 11.99 10.78 8 84839 23014 63381161
Basilar migraine 11.99 10.78 4 84843 52 63404123
Sinus node dysfunction 11.91 10.78 22 84825 4663 63399512
Peripheral venous disease 11.89 10.78 3 84844 15474 63388701
Hemiparesis 11.87 10.78 62 84785 23220 63380955
Pregnancy on contraceptive 11.85 10.78 11 84836 1181 63402994
Neuralgia 11.84 10.78 67 84780 25859 63378316
Mouth ulceration 11.77 10.78 80 84767 32904 63371271
Congenital foot malformation 11.75 10.78 6 84841 240 63403935
Anger 11.72 10.78 40 84807 12416 63391759
Skin oedema 11.70 10.78 10 84837 963 63403212
Gastric ulcer 11.68 10.78 9 84838 24028 63380147
Urine calcium decreased 11.67 10.78 3 84844 14 63404161
SJS-TEN overlap 11.66 10.78 7 84840 386 63403789
Neonatal hypotension 11.65 10.78 5 84842 134 63404041
Blood osmolarity increased 11.64 10.78 6 84841 245 63403930
Premature labour 11.63 10.78 40 84807 12464 63391711
Transfusion 11.60 10.78 3 84844 15214 63388961
Lip ulceration 11.58 10.78 14 84833 2036 63402139
Anal atresia 11.57 10.78 7 84840 391 63403784
Tooth malformation 11.50 10.78 3 84844 15 63404160
Enlarged cerebral perivascular spaces 11.50 10.78 3 84844 15 63404160
Congenital anomaly 11.48 10.78 13 84834 1763 63402412
Dermatitis bullous 11.47 10.78 31 84816 8477 63395698
Educational problem 11.44 10.78 7 84840 399 63403776
Hypotonia neonatal 11.43 10.78 11 84836 1235 63402940
Haemangioma 11.38 10.78 16 84831 2696 63401479
Depressive symptom 11.37 10.78 20 84827 4082 63400093
Gastroenteritis viral 11.35 10.78 9 84838 23691 63380484
Head injury 11.35 10.78 69 84778 27327 63376848
Drug level below therapeutic 11.32 10.78 22 84825 4844 63399331
Gastrooesophageal reflux disease 11.31 10.78 78 84769 95561 63308614
Grip strength decreased 11.27 10.78 8 84839 22279 63381896
Throat tightness 11.25 10.78 10 84837 24877 63379298
Granulocytopenia 11.24 10.78 24 84823 5648 63398527
Impaired driving ability 11.24 10.78 21 84826 4490 63399685
Inappropriate schedule of product administration 11.23 10.78 87 84760 103878 63300297
Respiratory disorder 11.21 10.78 22 84825 39060 63365115
Haemorrhoids 11.14 10.78 8 84839 22142 63382033
Poor venous access 11.11 10.78 3 84844 14782 63389393
Cytomegalovirus mucocutaneous ulcer 11.04 10.78 3 84844 18 63404157
Personality change 11.04 10.78 27 84820 6946 63397229
Haemorrhage 11.04 10.78 43 84804 60979 63343196
Visual field defect 11.03 10.78 26 84821 6535 63397640
Hallucination, visual 10.97 10.78 53 84794 19245 63384930
Sinus disorder 10.93 10.78 10 84837 24543 63379632
Blood pressure systolic increased 10.93 10.78 30 84817 47367 63356808
Unresponsive to stimuli 10.89 10.78 80 84767 33736 63370439
Trismus 10.84 10.78 19 84828 3866 63400309
Neurological examination abnormal 10.83 10.78 6 84841 284 63403891
Logorrhoea 10.82 10.78 15 84832 2495 63401680
Leukopenia 10.81 10.78 154 84693 77136 63327039
Laboratory test abnormal 10.80 10.78 12 84835 26900 63377275

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1062.52 11.52 1104 60405 103753 34791669
Drug reaction with eosinophilia and systemic symptoms 762.29 11.52 557 60952 32455 34862967
Generalised tonic-clonic seizure 369.89 11.52 303 61206 20871 34874551
Epilepsy 353.44 11.52 297 61212 21198 34874224
Anticonvulsant drug level increased 347.10 11.52 124 61385 1492 34893930
Status epilepticus 297.99 11.52 216 61293 12398 34883024
Stevens-Johnson syndrome 262.88 11.52 236 61273 18403 34877019
Aggression 251.40 11.52 326 61183 38638 34856784
Drug interaction 248.32 11.52 916 60593 225030 34670392
Ataxia 222.70 11.52 189 61320 13664 34881758
Death 206.17 11.52 239 61270 397810 34497612
Drug eruption 190.78 11.52 204 61305 19694 34875728
Gamma-glutamyltransferase increased 172.22 11.52 234 61275 28997 34866425
Somnolence 165.76 11.52 500 61009 110616 34784806
Toxicity to various agents 155.78 11.52 731 60778 199631 34695791
Nystagmus 154.81 11.52 99 61410 4616 34890806
Febrile neutropenia 150.78 11.52 29 61480 136820 34758602
Diarrhoea 144.20 11.52 294 61215 389618 34505804
Coordination abnormal 143.17 11.52 114 61395 7530 34887892
Anticonvulsant drug level above therapeutic 130.28 11.52 48 61461 634 34894788
Partial seizures 129.76 11.52 89 61420 4671 34890751
Dyspnoea 129.39 11.52 296 61213 376486 34518936
Overdose 127.57 11.52 401 61108 90658 34804764
Multiple-drug resistance 124.35 11.52 90 61419 5149 34890273
Petit mal epilepsy 117.16 11.52 71 61438 3007 34892415
Electroencephalogram abnormal 115.01 11.52 65 61444 2413 34893009
Sopor 112.06 11.52 122 61387 12014 34883408
Sudden unexplained death in epilepsy 111.48 11.52 39 61470 439 34894983
Eosinophilia 111.32 11.52 180 61329 26042 34869380
Lymphocyte stimulation test positive 109.84 11.52 43 61466 677 34894745
Hyponatraemia 108.39 11.52 356 61153 82335 34813087
Rash maculo-papular 107.02 11.52 185 61324 28266 34867156
Acute kidney injury 105.87 11.52 238 61271 304750 34590672
Psychogenic seizure 101.33 11.52 34 61475 334 34895088
Focal dyscognitive seizures 100.64 11.52 49 61460 1332 34894090
Pneumonia 98.75 11.52 319 61190 362308 34533114
Human herpes virus 6 serology positive 95.95 11.52 26 61483 111 34895311
Irritability 94.77 11.52 162 61347 24528 34870894
Abnormal behaviour 92.14 11.52 161 61348 24808 34870614
Anaemia 92.03 11.52 169 61340 233166 34662256
Drug level increased 91.51 11.52 150 61359 21946 34873476
Agitation 90.88 11.52 264 61245 57135 34838287
Toxic epidermal necrolysis 89.71 11.52 147 61362 21499 34873923
Drug level decreased 88.85 11.52 88 61421 7758 34887664
Trigeminal neuralgia 87.74 11.52 43 61466 1186 34894236
Lymphadenopathy 86.74 11.52 169 61340 28294 34867128
Dysarthria 85.45 11.52 189 61320 34593 34860829
Diplopia 81.76 11.52 123 61386 16720 34878702
Drug resistance 79.07 11.52 154 61355 25773 34869649
Sepsis 77.54 11.52 108 61401 166453 34728969
Anticonvulsant drug level decreased 77.34 11.52 38 61471 1054 34894368
Autism spectrum disorder 77.34 11.52 49 61460 2247 34893175
Arthralgia 75.48 11.52 114 61395 169927 34725495
Gastric lavage 74.82 11.52 14 61495 0 34895422
Loss of consciousness 74.09 11.52 315 61194 82352 34813070
Cross sensitivity reaction 74.05 11.52 40 61469 1357 34894065
Hyperammonaemia 73.19 11.52 72 61437 6295 34889127
Rash 72.32 11.52 652 60857 222100 34673322
Toxic skin eruption 71.40 11.52 94 61415 11291 34884131
Cardiac failure congestive 70.66 11.52 29 61480 83241 34812181
Dermatitis exfoliative 70.65 11.52 72 61437 6567 34888855
Dysmorphism 69.89 11.52 52 61457 3104 34892318
Myocardial infarction 68.72 11.52 67 61442 121018 34774404
Atrial fibrillation 66.86 11.52 70 61439 122323 34773099
Lymphocyte morphology abnormal 65.61 11.52 27 61482 487 34894935
Fatigue 64.84 11.52 385 61124 370268 34525154
Dyskinesia 63.38 11.52 129 61380 22284 34873138
Decreased eye contact 63.18 11.52 26 61483 469 34894953
Altered state of consciousness 62.66 11.52 130 61379 22763 34872659
Hypospadias 62.65 11.52 49 61460 3152 34892270
Bruxism 58.37 11.52 37 61472 1698 34893724
Aura 57.78 11.52 22 61487 320 34895102
Intentional self-injury 57.70 11.52 94 61415 13677 34881745
Gait disturbance 57.62 11.52 299 61210 84841 34810581
Oppositional defiant disorder 57.31 11.52 25 61484 524 34894898
Coma 56.55 11.52 193 61316 45485 34849937
Suicide attempt 56.30 11.52 174 61335 38942 34856480
Malignant neoplasm progression 55.64 11.52 44 61465 88002 34807420
Oral mucosa erosion 54.81 11.52 29 61480 943 34894479
Joint swelling 53.89 11.52 19 61490 59871 34835551
Gaze palsy 53.86 11.52 35 61474 1677 34893745
Off label use 52.14 11.52 480 61029 419044 34476378
Foetal exposure during pregnancy 51.63 11.52 166 61343 37935 34857487
Prostate cancer 51.62 11.52 5 61504 39644 34855778
Back pain 50.83 11.52 85 61424 121704 34773718
Excessive eye blinking 50.48 11.52 23 61486 536 34894886
Gastrointestinal haemorrhage 50.13 11.52 49 61460 88428 34806994
Mucosal erosion 49.92 11.52 26 61483 818 34894604
Rheumatoid arthritis 49.32 11.52 5 61504 38233 34857189
Psychomotor retardation 49.04 11.52 45 61464 3605 34891817
Depressed level of consciousness 47.85 11.52 175 61334 42666 34852756
Paraplegia 47.35 11.52 40 61469 2871 34892551
Exposure during pregnancy 47.33 11.52 68 61441 8866 34886556
Mania 46.93 11.52 70 61439 9441 34885981
Skin test positive 46.26 11.52 19 61490 341 34895081
Balance disorder 46.20 11.52 167 61342 40487 34854935
Neuropathy peripheral 46.15 11.52 47 61462 83216 34812206
Erythema multiforme 46.07 11.52 66 61443 8583 34886839
Hepatic adenoma 45.94 11.52 12 61497 43 34895379
Vertigo 45.85 11.52 123 61386 25413 34870009
Neuroleptic malignant syndrome 45.79 11.52 99 61410 17835 34877587
Cerebellar syndrome 45.54 11.52 36 61473 2352 34893070
Plasmapheresis 44.40 11.52 18 61491 312 34895110
Intentional overdose 44.31 11.52 173 61336 43501 34851921
Hypotension 44.29 11.52 220 61289 221429 34673993
Choreoathetosis 44.28 11.52 26 61483 1038 34894384
Drug level below therapeutic 44.25 11.52 52 61457 5563 34889859
Alanine aminotransferase increased 44.18 11.52 268 61241 80547 34814875
Inappropriate antidiuretic hormone secretion 44.16 11.52 80 61429 12673 34882749
Homicidal ideation 43.92 11.52 37 61472 2645 34892777
Head circumference abnormal 43.60 11.52 11 61498 33 34895389
Conjunctival hyperaemia 43.22 11.52 35 61474 2367 34893055
Human herpesvirus 6 infection 43.22 11.52 33 61476 2048 34893374
Dehydration 42.87 11.52 104 61405 129865 34765557
Hepatic function abnormal 42.81 11.52 173 61336 44190 34851232
Sedation 42.68 11.52 106 61403 20900 34874522
Congenital nail disorder 42.65 11.52 11 61498 37 34895385
Renal failure 42.64 11.52 105 61404 130452 34764970
Product dose omission issue 42.55 11.52 92 61417 119619 34775803
Speech disorder 42.42 11.52 120 61389 25566 34869856
Product complaint 42.25 11.52 52 61457 5838 34889584
Psychotic disorder 42.12 11.52 116 61393 24336 34871086
Nausea 42.12 11.52 389 61120 339519 34555903
Psychomotor hyperactivity 42.11 11.52 67 61442 9555 34885867
Hyperammonaemic encephalopathy 42.11 11.52 34 61475 2290 34893132
Weight decreased 41.86 11.52 164 61345 176137 34719285
COVID-19 41.60 11.52 45 61464 77505 34817917
Tonic convulsion 41.38 11.52 26 61483 1175 34894247
Drug ineffective 41.10 11.52 1072 60437 455679 34439743
Abdominal pain 40.91 11.52 149 61360 163469 34731953
Altered pitch perception 40.50 11.52 9 61500 12 34895410
Skin exfoliation 40.37 11.52 123 61386 27309 34868113
Intentional product use issue 40.22 11.52 28 61481 59788 34835634
Disease progression 40.14 11.52 81 61428 107996 34787426
Chest pain 39.81 11.52 104 61405 126658 34768764
Aspartate aminotransferase increased 39.75 11.52 229 61280 67554 34827868
Face oedema 39.57 11.52 72 61437 11444 34883978
Middle insomnia 39.35 11.52 54 61455 6748 34888674
Neonatal pneumonia 39.27 11.52 13 61496 122 34895300
Hospitalisation 39.11 11.52 26 61483 56876 34838546
Posture abnormal 38.98 11.52 32 61477 2207 34893215
Cognitive disorder 38.86 11.52 125 61384 28568 34866854
Anticonvulsant drug level below therapeutic 38.46 11.52 20 61489 627 34894795
Asterixis 38.28 11.52 25 61484 1208 34894214
Hypotonia 37.61 11.52 57 61452 7796 34887626
Postictal psychosis 37.59 11.52 14 61495 191 34895231
Coronary artery disease 37.57 11.52 19 61490 48286 34847136
Product substitution issue 37.10 11.52 65 61444 10030 34885392
Neonatal hypotension 36.95 11.52 13 61496 149 34895273
Ascites 36.70 11.52 18 61491 46553 34848869
Roseolovirus test positive 36.69 11.52 11 61498 72 34895350
Peripheral swelling 36.20 11.52 49 61460 76492 34818930
Simple partial seizures 36.13 11.52 15 61494 277 34895145
Lip erosion 35.93 11.52 19 61490 617 34894805
Apathy 35.61 11.52 52 61457 6880 34888542
Oedema peripheral 35.59 11.52 101 61408 119711 34775711
Pain 35.45 11.52 213 61296 204462 34690960
Neutropenia 35.22 11.52 149 61360 156629 34738793
Blood lactate dehydrogenase increased 34.69 11.52 104 61405 22886 34872536
Agnosia 34.23 11.52 10 61499 59 34895363
Intellectual disability 34.08 11.52 24 61485 1314 34894108
Bradyphrenia 33.84 11.52 42 61467 4756 34890666
Disturbance in attention 33.31 11.52 111 61398 25834 34869588
Delusion 32.54 11.52 70 61439 12565 34882857
Radiation inflammation 32.21 11.52 20 61489 885 34894537
Completed suicide 32.07 11.52 288 61221 97880 34797542
Septic shock 31.97 11.52 48 61461 71786 34823636
Crying 31.61 11.52 45 61464 5817 34889605
Eosinophil count increased 31.25 11.52 55 61454 8517 34886905
Lymphocytic infiltration 31.15 11.52 18 61491 697 34894725
Pain in extremity 31.09 11.52 116 61393 126397 34769025
Cardiac failure 30.88 11.52 72 61437 91176 34804246
Postictal paralysis 30.78 11.52 13 61496 251 34895171
Hyperkinesia 30.21 11.52 25 61484 1743 34893679
Epistaxis 29.93 11.52 35 61474 58216 34837206
Blood alkaline phosphatase increased 29.61 11.52 121 61388 31054 34864368
Myoclonus 29.59 11.52 74 61435 14651 34880771
Foetal anticonvulsant syndrome 29.56 11.52 21 61488 1166 34894256
Infusion related reaction 29.33 11.52 30 61479 53027 34842395
Plasma cell myeloma 29.17 11.52 19 61490 42018 34853404
Microcephaly 29.06 11.52 18 61491 793 34894629
Bradykinesia 28.95 11.52 35 61474 3858 34891564
Chest discomfort 28.84 11.52 32 61477 54498 34840924
Thrombosis 28.50 11.52 28 61481 50430 34844992
Psychiatric symptom 28.46 11.52 33 61476 3480 34891942
Mood altered 28.29 11.52 54 61455 8898 34886524
Dysmetria 28.26 11.52 16 61493 596 34894826
Temporal lobe epilepsy 28.11 11.52 11 61498 173 34895249
Acute myocardial infarction 27.90 11.52 32 61477 53687 34841735
Non-24-hour sleep-wake disorder 27.50 11.52 7 61502 22 34895400
Infection 27.47 11.52 76 61433 90839 34804583
Myalgia 27.17 11.52 68 61441 84042 34811380
Erythema 26.75 11.52 256 61253 88524 34806898
Pulmonary pain 26.73 11.52 20 61489 1204 34894218
Skin erosion 26.65 11.52 25 61484 2060 34893362
Clumsiness 26.54 11.52 23 61486 1709 34893713
Decreased appetite 26.31 11.52 178 61331 166214 34729208
Hyperexplexia 25.62 11.52 7 61502 31 34895391
Meningocele 25.44 11.52 7 61502 32 34895390
Low birth weight baby 25.37 11.52 48 61461 7857 34887565
Epileptic aura 25.17 11.52 6 61503 13 34895409
Arthritis 24.87 11.52 12 61497 31334 34864088
Mucosal inflammation 24.76 11.52 19 61490 38603 34856819
Pleural effusion 24.76 11.52 68 61441 81478 34813944
Frontotemporal dementia 24.73 11.52 11 61498 242 34895180
Partial seizures with secondary generalisation 24.72 11.52 12 61497 324 34895098
Trismus 24.64 11.52 26 61483 2469 34892953
Dyspraxia 24.53 11.52 13 61496 424 34894998
Constipation 24.51 11.52 141 61368 136841 34758581
Renal phospholipidosis 24.38 11.52 5 61504 3 34895419
Epileptic psychosis 24.30 11.52 6 61503 16 34895406
Genital erosion 24.24 11.52 11 61498 254 34895168
Hyperdynamic left ventricle 24.12 11.52 10 61499 184 34895238
Developmental delay 24.06 11.52 27 61482 2748 34892674
Cellulitis 23.93 11.52 35 61474 52916 34842506
Pneumonitis 23.93 11.52 15 61494 33863 34861559
Pneumonia aspiration 23.54 11.52 140 61369 41763 34853659
Gingival atrophy 23.32 11.52 7 61502 46 34895376
Thinking abnormal 23.18 11.52 40 61469 6097 34889325
Personality disorder 23.12 11.52 18 61491 1150 34894272
Epidermal necrosis 23.11 11.52 13 61496 478 34894944
Accidental overdose 23.10 11.52 83 61426 20057 34875365
Liver disorder 23.07 11.52 117 61392 32880 34862542
Apgar score low 22.67 11.52 16 61493 879 34894543
Facial pain 22.32 11.52 30 61479 3674 34891748
Congenital cystic lung 22.31 11.52 10 61499 224 34895198
Diabetic neuropathy 22.31 11.52 32 61477 4165 34891257
Schizophrenia 22.30 11.52 48 61461 8618 34886804
Change in seizure presentation 22.25 11.52 9 61500 155 34895267
Loose associations 22.24 11.52 7 61502 55 34895367
Water intoxication 21.98 11.52 12 61497 416 34895006
Full blood count decreased 21.75 11.52 3 61506 18085 34877337
Neurodevelopmental disorder 21.74 11.52 12 61497 425 34894997
Wrong patient received product 21.62 11.52 25 61484 2629 34892793
Blood pressure increased 21.49 11.52 81 61428 88021 34807401
Tremor 21.45 11.52 231 61278 82356 34813066
Sinusitis 21.13 11.52 25 61484 41377 34854045
Drowning 21.05 11.52 12 61497 453 34894969
Hepatosplenomegaly 21.02 11.52 31 61478 4138 34891284
Affect lability 20.94 11.52 29 61480 3654 34891768
Atonic seizures 20.87 11.52 10 61499 262 34895160
Abdominal distension 20.72 11.52 45 61464 58447 34836975
Hyperpyrexia 20.62 11.52 25 61484 2763 34892659
Sinus arrest 20.60 11.52 20 61489 1720 34893702
Bone marrow failure 20.60 11.52 13 61496 29240 34866182
Hangover 20.38 11.52 16 61493 1035 34894387
Acute generalised exanthematous pustulosis 20.35 11.52 40 61469 6736 34888686
Congenital anomaly 20.34 11.52 18 61491 1375 34894047
Medication error 20.28 11.52 94 61415 25471 34869951
Rash morbilliform 20.15 11.52 26 61483 3061 34892361
Rash pustular 20.11 11.52 35 61474 5373 34890049
Personality change 20.08 11.52 34 61475 5105 34890317
Depressed mood 19.97 11.52 77 61432 19240 34876182
Emotional disorder 19.97 11.52 36 61473 5680 34889742
Chronic kidney disease 19.86 11.52 26 61483 41184 34854238
Antisocial behaviour 19.77 11.52 11 61498 396 34895026
Papule 19.76 11.52 30 61479 4109 34891313
Haemoglobin decreased 19.68 11.52 128 61381 120644 34774778
Blister 19.60 11.52 86 61423 22772 34872650
Hypoventilation 19.59 11.52 27 61482 3387 34892035
Guillain-Barre syndrome 19.59 11.52 37 61472 6050 34889372
Micrognathia 19.51 11.52 10 61499 304 34895118
Haemorrhage 19.48 11.52 38 61471 51332 34844090
Dysphagia 19.34 11.52 181 61328 62200 34833222
Gout 19.32 11.52 5 61504 19248 34876174
Enanthema 19.25 11.52 11 61498 417 34895005
Condition aggravated 19.20 11.52 458 61051 191738 34703684
Anger 19.11 11.52 55 61454 11829 34883593
Pyrexia 19.11 11.52 741 60768 332272 34563150
Suicidal ideation 19.00 11.52 129 61380 40259 34855163
Communication disorder 18.91 11.52 23 61486 2551 34892871
Lymphocytosis 18.89 11.52 23 61486 2554 34892868
Bone metabolism disorder 18.68 11.52 9 61500 239 34895183
Cardiogenic shock 18.51 11.52 12 61497 26606 34868816
Hyporeflexia 18.38 11.52 20 61489 1967 34893455
Stomatitis 18.34 11.52 29 61480 42485 34852937
Extrapyramidal disorder 18.24 11.52 57 61452 12823 34882599
Tracheo-oesophageal fistula 18.21 11.52 11 61498 463 34894959
Oculomucocutaneous syndrome 18.19 11.52 8 61501 171 34895251
Angina pectoris 18.18 11.52 17 61492 31346 34864076
Perseveration 18.07 11.52 7 61502 107 34895315
Drug withdrawal syndrome 18.06 11.52 76 61433 19758 34875664
Respiratory disorder neonatal 17.93 11.52 18 61491 1612 34893810
Cerebellar ataxia 17.92 11.52 15 61494 1063 34894359
Hypomagnesaemia 17.90 11.52 8 61501 21843 34873579
Osteoarthritis 17.80 11.52 7 61502 20635 34874787
Hypertension 17.76 11.52 154 61355 136289 34759133
Fluid retention 17.53 11.52 13 61496 26874 34868548
General physical health deterioration 17.50 11.52 143 61366 128126 34767296
Injection site pain 17.41 11.52 26 61483 38979 34856443
Contraindicated product administered 17.38 11.52 8 61501 21473 34873949
Osteonecrosis of jaw 17.28 11.52 5 61504 17884 34877538
Ultrasound liver abnormal 17.23 11.52 7 61502 122 34895300
Rash erythematous 17.06 11.52 88 61421 24889 34870533
Motor developmental delay 17.06 11.52 12 61497 656 34894766
Dysgeusia 17.03 11.52 13 61496 26484 34868938
Strabismus 17.03 11.52 18 61491 1713 34893709
Blood sodium decreased 16.98 11.52 65 61444 16186 34879236
Cheilitis 16.97 11.52 21 61488 2370 34893052
Influenza 16.94 11.52 39 61470 49627 34845795
Diverticulitis 16.90 11.52 7 61502 19997 34875425
Skin ulcer 16.88 11.52 9 61500 22207 34873215
Contraindicated product prescribed 16.86 11.52 10 61499 407 34895015
Rectal haemorrhage 16.85 11.52 28 61481 40221 34855201
Localised infection 16.84 11.52 5 61504 17582 34877840
Hyperkalaemia 16.78 11.52 64 61445 69325 34826097
Bladder cancer 16.77 11.52 4 61505 16274 34879148
Memory impairment 16.74 11.52 132 61377 43186 34852236
Lactic acidosis 16.69 11.52 22 61487 34750 34860672
Sedation complication 16.64 11.52 18 61491 1759 34893663
Bacteraemia 16.50 11.52 7 61502 19710 34875712
Hypertrophic scar 16.38 11.52 4 61505 10 34895412
Language disorder 16.31 11.52 20 61489 2236 34893186
Unevaluable event 16.29 11.52 20 61489 32570 34862852
Psoriasis 16.25 11.52 27 61482 38785 34856637
Mouth ulceration 16.22 11.52 52 61457 11858 34883564
Atypical benign partial epilepsy 16.03 11.52 3 61506 0 34895422
Mental disorder 16.03 11.52 61 61448 15148 34880274
Suspiciousness 16.02 11.52 9 61500 330 34895092
Abdominal pain upper 15.99 11.52 68 61441 71422 34824000
Arachnoid cyst 15.96 11.52 8 61501 232 34895190
Haemoptysis 15.95 11.52 23 61486 34983 34860439
Body height below normal 15.89 11.52 8 61501 234 34895188
Brain oedema 15.88 11.52 57 61452 13764 34881658
Mental impairment 15.86 11.52 47 61462 10275 34885147
Muscle spasms 15.77 11.52 73 61436 74928 34820494
Haematuria 15.75 11.52 41 61468 50025 34845397
Osteomalacia 15.74 11.52 13 61496 904 34894518
Conduction disorder 15.74 11.52 19 61490 2091 34893331
Potentiating drug interaction 15.70 11.52 30 61479 4947 34890475
Labelled drug-food interaction medication error 15.70 11.52 5 61504 41 34895381
Learning disability 15.66 11.52 9 61500 345 34895077
Open angle glaucoma 15.61 11.52 7 61502 157 34895265
Haematochezia 15.51 11.52 37 61472 46497 34848925
Renal impairment 15.47 11.52 100 61409 94413 34801009
Psychomotor skills impaired 15.47 11.52 26 61483 3880 34891542
Premature baby 15.43 11.52 72 61437 19561 34875861
Bone density decreased 15.43 11.52 18 61491 1911 34893511
Cardiac disorder 15.42 11.52 33 61476 43093 34852329
Parkinsonism 15.42 11.52 40 61469 8098 34887324
Histiocytic necrotising lymphadenitis 15.39 11.52 4 61505 14 34895408
Brain malformation 15.37 11.52 7 61502 163 34895259
Xanthoma 15.35 11.52 6 61503 94 34895328
Poriomania 15.35 11.52 6 61503 94 34895328
Stupor 15.31 11.52 22 61487 2869 34892553
Xanthelasma 15.29 11.52 6 61503 95 34895327
Acute hepatic failure 15.29 11.52 57 61452 14017 34881405
Rhesus incompatibility 15.29 11.52 5 61504 45 34895377
Pressure of speech 15.28 11.52 10 61499 485 34894937
Chills 15.26 11.52 82 61427 80961 34814461
Multiple organ dysfunction syndrome 15.24 11.52 76 61433 76490 34818932
Distractibility 15.20 11.52 9 61500 365 34895057
Maternal drugs affecting foetus 15.18 11.52 26 61483 3939 34891483
Prominent epicanthal folds 15.18 11.52 7 61502 168 34895254
Torticollis 15.06 11.52 14 61495 1140 34894282
Myoclonic epilepsy 15.03 11.52 14 61495 1143 34894279
Hypervolaemia 14.95 11.52 8 61501 19701 34875721
Rickets 14.91 11.52 5 61504 49 34895373
Basal cell carcinoma 14.88 11.52 8 61501 19650 34875772
Salivary hypersecretion 14.87 11.52 41 61468 8603 34886819
Restlessness 14.86 11.52 86 61423 25396 34870026
Withdrawal syndrome 14.85 11.52 52 61457 12403 34883019
Mucosal ulceration 14.82 11.52 13 61496 982 34894440
Oxygen saturation decreased 14.79 11.52 47 61462 53771 34841651
Colectomy total 14.77 11.52 7 61502 179 34895243
Ventricular tachycardia 14.72 11.52 15 61494 26564 34868858
Gastric hypomotility 14.64 11.52 6 61503 107 34895315
Therapeutic response unexpected 14.58 11.52 44 61465 9713 34885709
Facial bones fracture 14.56 11.52 20 61489 2500 34892922
Appendicitis 14.56 11.52 4 61505 14803 34880619
Tonic clonic movements 14.55 11.52 13 61496 1006 34894416
Nervousness 14.49 11.52 52 61457 12554 34882868
Dystonia 14.45 11.52 47 61462 10798 34884624
Nikolsky's sign 14.25 11.52 7 61502 194 34895228
Cataract 14.25 11.52 15 61494 26171 34869251
Death of relative 14.25 11.52 4 61505 20 34895402
Dry age-related macular degeneration 14.25 11.52 6 61503 115 34895307
Therapy cessation 14.24 11.52 6 61503 16967 34878455
Haemorrhoids 14.22 11.52 4 61505 14571 34880851
Sitting disability 14.15 11.52 7 61502 197 34895225
Flatulence 14.14 11.52 10 61499 21188 34874234
Clostridium difficile colitis 14.13 11.52 5 61504 15725 34879697
Rash papular 14.11 11.52 45 61464 10233 34885189
Multiple sclerosis 13.99 11.52 34 61475 6611 34888811
Biopsy lymph gland abnormal 13.96 11.52 3 61506 3 34895419
Kluver-Bucy syndrome 13.96 11.52 3 61506 3 34895419
Hypoxia 13.86 11.52 50 61459 55045 34840377
Head injury 13.84 11.52 66 61443 18094 34877328
Conjunctivitis 13.79 11.52 43 61466 9662 34885760
Cholinergic syndrome 13.74 11.52 10 61499 577 34894845
Glomerular filtration rate decreased 13.72 11.52 3 61506 12958 34882464
Genital ulceration 13.72 11.52 9 61500 438 34894984
Onychophagia 13.71 11.52 5 61504 64 34895358
Paresis 13.63 11.52 18 61491 2168 34893254
Eosinophilic oesophagitis 13.59 11.52 8 61501 321 34895101
Abulia 13.54 11.52 10 61499 590 34894832
Acute respiratory failure 13.43 11.52 21 61488 30907 34864515
Measles 13.39 11.52 7 61502 222 34895200
Ammonia increased 13.37 11.52 26 61483 4343 34891079
Maternal exposure during breast feeding 13.37 11.52 15 61494 1526 34893896
Low set ears 13.33 11.52 9 61500 460 34894962
Rebound effect 13.24 11.52 22 61487 3252 34892170
Patient uncooperative 13.23 11.52 9 61500 466 34894956
Fall 13.19 11.52 458 61051 202427 34692995
Poverty of speech 13.19 11.52 7 61502 229 34895193
Seizure cluster 13.12 11.52 6 61503 141 34895281
Feeling of despair 13.04 11.52 12 61497 965 34894457
Cryptorchism 13.02 11.52 17 61492 2024 34893398
Cerebral palsy 12.93 11.52 6 61503 146 34895276
Hypochloraemia 12.90 11.52 10 61499 635 34894787
Congenital arterial malformation 12.89 11.52 6 61503 147 34895275
Leukoplakia oral 12.87 11.52 5 61504 77 34895345
Metastases to liver 12.87 11.52 4 61505 13659 34881763
Paradoxical drug reaction 12.87 11.52 22 61487 3329 34892093
Attention deficit hyperactivity disorder 12.86 11.52 19 61490 2540 34892882
Blood glucose increased 12.84 11.52 67 61442 66651 34828771
Tumour lysis syndrome 12.83 11.52 7 61502 17052 34878370
Nephrolithiasis 12.79 11.52 21 61488 30312 34865110
Subacute cutaneous lupus erythematosus 12.78 11.52 12 61497 990 34894432
Trigeminal nerve disorder 12.76 11.52 4 61505 31 34895391
Human herpesvirus 7 infection 12.75 11.52 3 61506 6 34895416
Bronchitis 12.72 11.52 35 61474 41928 34853494
Melaena 12.71 11.52 27 61482 35353 34860069
Sinus node dysfunction 12.66 11.52 25 61484 4224 34891198
Conjunctival disorder 12.53 11.52 5 61504 83 34895339
Clostridium difficile infection 12.50 11.52 9 61500 18889 34876533
Palmar-plantar erythrodysaesthesia syndrome 12.47 11.52 7 61502 16788 34878634
Coma scale abnormal 12.45 11.52 24 61485 3984 34891438
Blood creatinine increased 12.44 11.52 107 61402 94869 34800553
Drug abuse 12.39 11.52 244 61265 98852 34796570
Impulsive behaviour 12.26 11.52 17 61492 2145 34893277
Staring 12.23 11.52 14 61495 1456 34893966
Metastases to bone 12.22 11.52 3 61506 11967 34883455
Blood urea decreased 12.21 11.52 12 61497 1047 34894375
Salivary gland calculus 12.21 11.52 5 61504 89 34895333
Treatment noncompliance 12.19 11.52 88 61421 28012 34867410
Liver function test abnormal 12.17 11.52 95 61414 30979 34864443
Ischaemic gastritis 12.15 11.52 3 61506 8 34895414
Eyelid erosion 12.15 11.52 3 61506 8 34895414
Hypercalcaemia 12.15 11.52 6 61503 15462 34879960
Hypercapnic coma 12.06 11.52 6 61503 171 34895251
Regressive behaviour 12.04 11.52 4 61505 38 34895384
Cerebellar atrophy 11.98 11.52 9 61500 545 34894877
Mycoplasma infection 11.95 11.52 8 61501 403 34895019
Photophobia 11.95 11.52 33 61476 6931 34888491
Cough 11.93 11.52 189 61320 149951 34745471
Pigmentation disorder 11.93 11.52 18 61491 2451 34892971
Drug half-life reduced 11.89 11.52 3 61506 9 34895413
Blood lactate dehydrogenase 11.89 11.52 3 61506 9 34895413
Wrong schedule 11.84 11.52 6 61503 178 34895244
Multiple congenital abnormalities 11.84 11.52 9 61500 555 34894867
Shock 11.84 11.52 78 61431 24101 34871321
Anaplastic large cell lymphoma T- and null-cell types 11.82 11.52 5 61504 97 34895325
Blood osmolarity decreased 11.74 11.52 9 61500 562 34894860
Phonophobia 11.72 11.52 6 61503 182 34895240
Trigemino-cardiac reflex 11.57 11.52 6 61503 187 34895235
Tardive dyskinesia 11.53 11.52 29 61480 5761 34889661

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 1568.00 10.35 1057 119405 63187 79560739
Seizure 1449.75 10.35 1599 118863 187235 79436691
Toxicity to various agents 842.70 10.35 1920 118542 419620 79204306
Generalised tonic-clonic seizure 678.58 10.35 549 119913 43361 79580565
Drug interaction 678.20 10.35 1750 118712 413433 79210493
Sedation complication 630.44 10.35 355 120107 15314 79608612
Cognitive disorder 592.88 10.35 625 119837 69301 79554625
Epilepsy 587.64 10.35 490 119972 40370 79583556
Status epilepticus 572.32 10.35 396 120066 24645 79599281
Balance disorder 571.21 10.35 725 119737 98132 79525794
Anticonvulsant drug level increased 570.58 10.35 196 120266 2457 79621469
Sedation 567.90 10.35 533 119929 51362 79572564
Creatinine renal clearance decreased 539.47 10.35 344 120118 18658 79605268
Depressed level of consciousness 536.66 10.35 695 119767 95957 79527969
Stevens-Johnson syndrome 518.76 10.35 448 120014 38718 79585208
Ataxia 433.89 10.35 335 120127 24704 79599222
Blood calcium decreased 427.52 10.35 367 120095 31452 79592474
Orthostatic hypotension 387.88 10.35 451 120011 55713 79568213
Overdose 359.90 10.35 833 119629 183373 79440553
Aggression 356.58 10.35 412 120050 50546 79573380
Hyponatraemia 337.31 10.35 795 119667 177053 79446873
Somnolence 325.83 10.35 944 119518 238037 79385889
Diarrhoea 306.83 10.35 539 119923 879950 78743976
Nystagmus 297.86 10.35 186 120276 9718 79614208
Dyspnoea 275.25 10.35 551 119911 856474 78767452
Petit mal epilepsy 261.26 10.35 141 120321 5586 79618340
Psychotic disorder 260.32 10.35 317 120145 41085 79582841
Arthralgia 259.73 10.35 289 120173 571514 79052412
Drug eruption 259.54 10.35 326 120136 43609 79580317
Joint swelling 249.80 10.35 64 120398 288582 79335344
Drug level increased 245.10 10.35 301 120161 39350 79584576
Partial seizures 236.25 10.35 155 120307 8823 79615103
Diplopia 231.43 10.35 269 120193 33197 79590729
Rheumatoid arthritis 224.41 10.35 26 120436 208444 79415482
Electroencephalogram abnormal 223.66 10.35 125 120337 5309 79618617
Focal dyscognitive seizures 219.79 10.35 107 120355 3405 79620521
Schizophrenia 219.48 10.35 184 120278 15256 79608670
Rash maculo-papular 218.87 10.35 341 120121 55737 79568189
Gamma-glutamyltransferase increased 215.51 10.35 334 120128 54346 79569580
Febrile neutropenia 212.16 10.35 45 120417 230954 79392972
Synovitis 211.92 10.35 3 120459 150731 79473195
Coma 209.51 10.35 467 119995 100182 79523744
Anticonvulsant drug level above therapeutic 207.83 10.35 75 120387 1096 79622830
Toxic epidermal necrolysis 198.05 10.35 288 120174 44293 79579633
Sopor 193.46 10.35 244 120218 32766 79591160
Multiple-drug resistance 188.86 10.35 134 120328 8674 79615252
Dysarthria 188.38 10.35 354 120108 67268 79556658
Infusion related reaction 188.06 10.35 57 120405 230180 79393746
Eosinophilia 185.75 10.35 282 120180 45063 79578863
Suicide attempt 181.89 10.35 393 120069 82539 79541387
Drug level decreased 179.09 10.35 159 120303 14243 79609683
Peripheral swelling 175.87 10.35 94 120368 269523 79354403
Death 167.41 10.35 381 120081 566133 79057793
Loss of consciousness 167.23 10.35 596 119866 167347 79456579
Contraindicated product administered 163.79 10.35 22 120440 157516 79466410
Sudden unexplained death in epilepsy 161.94 10.35 54 120408 614 79623312
Completed suicide 161.44 10.35 767 119695 245000 79378926
Coordination abnormal 159.67 10.35 162 120300 17150 79606776
Fatigue 156.32 10.35 799 119663 928928 78694998
Irritability 153.35 10.35 245 120217 40899 79583027
Altered state of consciousness 148.54 10.35 250 120212 43572 79580354
Abnormal behaviour 148.45 10.35 226 120236 36195 79587731
Fall 148.23 10.35 1249 119213 486380 79137546
Intentional overdose 147.45 10.35 422 120040 105538 79518388
Sinusitis 146.45 10.35 56 120406 195445 79428481
Psychogenic seizure 145.92 10.35 67 120395 1864 79622062
Hand deformity 142.21 10.35 3 120459 103916 79520010
Jaundice cholestatic 139.16 10.35 124 120338 11160 79612766
Anaemia 137.36 10.35 292 120170 444723 79179203
Drug resistance 135.41 10.35 235 120227 41978 79581948
Inappropriate antidiuretic hormone secretion 133.21 10.35 181 120281 26132 79597794
Acute kidney injury 132.72 10.35 376 120086 519028 79104898
Human herpes virus 6 serology positive 128.81 10.35 35 120427 182 79623744
Swelling 127.99 10.35 85 120377 216626 79407300
Lymphocyte stimulation test positive 127.24 10.35 52 120410 1081 79622845
Trigeminal neuralgia 127.09 10.35 75 120387 3534 79620392
Hyperammonaemia 125.23 10.35 116 120346 10977 79612949
Pericarditis 122.79 10.35 9 120453 104227 79519699
Erythema multiforme 122.22 10.35 142 120320 17509 79606417
Alopecia 120.90 10.35 103 120359 231252 79392674
Hyperammonaemic encephalopathy 119.62 10.35 80 120382 4702 79619224
Mobility decreased 119.36 10.35 431 120031 121744 79502182
Agitation 117.88 10.35 375 120087 99340 79524586
Cross sensitivity reaction 117.41 10.35 72 120390 3640 79620286
Pemphigus 116.17 10.35 9 120453 99573 79524353
Dermatitis exfoliative 116.03 10.35 110 120352 10719 79613207
Lymphadenopathy 115.20 10.35 251 120211 52996 79570930
Drug intolerance 111.60 10.35 141 120321 263978 79359948
Anticonvulsant drug level decreased 109.37 10.35 55 120407 1879 79622047
Back pain 107.42 10.35 184 120278 303996 79319930
Abdominal discomfort 106.81 10.35 133 120329 250594 79373332
Intentional product use issue 105.20 10.35 49 120413 152063 79471863
Arthropathy 103.85 10.35 70 120392 177041 79446885
Wound 103.85 10.35 24 120438 116155 79507771
Drug abuse 101.87 10.35 501 119961 162190 79461736
Oral mucosa erosion 97.46 10.35 51 120411 1896 79622030
Glossodynia 97.16 10.35 19 120443 103318 79520608
Infection 96.03 10.35 135 120327 241577 79382349
Anticonvulsant drug level below therapeutic 96.03 10.35 42 120420 1039 79622887
Intentional self-injury 95.64 10.35 174 120288 32245 79591681
Pain in extremity 92.92 10.35 264 120198 364274 79259652
Mucosal erosion 91.81 10.35 52 120410 2266 79621660
Neuroleptic malignant syndrome 91.76 10.35 156 120306 27403 79596523
Pneumonia 91.59 10.35 603 119859 659643 78964283
Hepatic function abnormal 91.06 10.35 280 120182 72827 79551099
Systemic lupus erythematosus 90.20 10.35 35 120427 121114 79502812
Myoclonus 90.03 10.35 155 120307 27505 79596421
Myocardial infarction 89.03 10.35 88 120374 184041 79439885
Speech disorder 87.84 10.35 229 120233 54216 79569710
Lymphocyte morphology abnormal 87.64 10.35 38 120424 920 79623006
Arthritis 87.52 10.35 32 120430 114848 79509078
Toxic skin eruption 86.17 10.35 135 120327 22158 79601768
Gastric lavage 85.83 10.35 20 120442 47 79623879
Myoclonic epilepsy 85.69 10.35 47 120415 1923 79622003
Cerebellar syndrome 85.61 10.35 69 120393 5411 79618515
Aura 84.98 10.35 37 120425 905 79623021
Bradyphrenia 84.61 10.35 92 120370 10548 79613378
Vertigo 82.72 10.35 261 120201 68821 79555105
Cardiac failure congestive 82.51 10.35 57 120405 142345 79481581
Psoriatic arthropathy 80.79 10.35 11 120451 77988 79545938
Tonic convulsion 80.45 10.35 47 120415 2173 79621753
Therapeutic product effect decreased 78.43 10.35 79 120383 163784 79460142
Chest pain 77.53 10.35 197 120265 282107 79341819
Discomfort 77.25 10.35 47 120415 125570 79498356
Rheumatoid factor positive 77.21 10.35 3 120459 59836 79564090
Abdominal pain 76.30 10.35 316 120146 389253 79234673
Neuropathy peripheral 76.15 10.35 61 120401 141244 79482682
Intellectual disability 76.00 10.35 38 120424 1282 79622644
Impaired healing 74.66 10.35 20 120442 87635 79536291
Face oedema 73.04 10.35 143 120319 27993 79595933
Malignant neoplasm progression 72.91 10.35 59 120403 135931 79487995
Human herpesvirus 6 infection 72.22 10.35 62 120400 5308 79618618
Nausea 72.18 10.35 1016 119446 956180 78667746
Gastrointestinal haemorrhage 72.09 10.35 70 120392 147649 79476277
Hypotonia 72.03 10.35 93 120369 12777 79611149
Nasopharyngitis 71.39 10.35 175 120287 253706 79370220
Gait disturbance 70.13 10.35 545 119917 206961 79416965
Gaze palsy 69.75 10.35 48 120414 2957 79620969
Helicobacter infection 69.48 10.35 11 120451 69693 79554233
Off label use 69.07 10.35 961 119501 906254 78717672
Sepsis 67.97 10.35 196 120266 269232 79354694
General physical health deterioration 67.43 10.35 203 120259 275035 79348891
Temporal lobe epilepsy 66.02 10.35 25 120437 421 79623505
Dyskinesia 64.86 10.35 181 120281 44592 79579334
Mania 64.31 10.35 106 120356 18154 79605772
Atrial fibrillation 64.20 10.35 126 120336 197760 79426166
Oppositional defiant disorder 63.39 10.35 25 120437 472 79623454
COVID-19 62.66 10.35 88 120374 157586 79466340
Decreased eye contact 62.20 10.35 29 120433 836 79623090
Folliculitis 61.87 10.35 6 120456 55374 79568552
Lip erosion 61.80 10.35 35 120427 1525 79622401
Product dose omission issue 61.76 10.35 181 120281 247356 79376570
Simple partial seizures 61.39 10.35 27 120435 677 79623249
Delusion 60.72 10.35 110 120352 20313 79603613
Osteoarthritis 60.54 10.35 28 120434 87281 79536645
Suicidal ideation 60.39 10.35 252 120210 76088 79547838
Abdominal pain upper 60.04 10.35 158 120304 223661 79400265
Psychomotor hyperactivity 59.59 10.35 98 120364 16751 79607175
Weight decreased 59.50 10.35 305 120157 354893 79269033
Pyrexia 59.18 10.35 1391 119071 677318 78946608
Hypersensitivity 58.93 10.35 201 120261 262038 79361888
Disease progression 57.57 10.35 120 120342 184242 79439684
Partial seizures with secondary generalisation 57.25 10.35 25 120437 616 79623310
Stomatitis 57.23 10.35 83 120379 146674 79477252
Total lung capacity increased 56.41 10.35 38 120424 2260 79621666
Extrapyramidal disorder 56.14 10.35 113 120349 22566 79601360
Fibromyalgia 54.19 10.35 15 120447 64325 79559601
Skin test positive 53.81 10.35 29 120433 1145 79622781
Choreoathetosis 53.64 10.35 32 120430 1538 79622388
Conjunctival hyperaemia 53.43 10.35 48 120414 4365 79619561
Product use issue 52.64 10.35 153 120309 209669 79414257
Altered pitch perception 51.90 10.35 11 120451 13 79623913
Irritable bowel syndrome 51.52 10.35 15 120447 62226 79561700
Product substitution issue 51.43 10.35 102 120360 20154 79603772
Injection site pain 51.05 10.35 73 120389 129765 79494161
Hyporeflexia 49.63 10.35 42 120420 3526 79620400
Atonic seizures 49.61 10.35 24 120438 753 79623173
Skin erosion 49.24 10.35 46 120416 4399 79619527
Pulmonary pain 49.00 10.35 46 120416 4427 79619499
Gastrointestinal disorder 48.75 10.35 68 120394 122137 79501789
Blood lactate dehydrogenase increased 48.74 10.35 150 120312 39020 79584906
Change in seizure presentation 48.71 10.35 21 120441 501 79623425
Asterixis 48.59 10.35 37 120425 2670 79621256
Alanine aminotransferase increased 47.39 10.35 413 120049 162157 79461769
Headache 47.00 10.35 700 119762 653072 78970854
Apathy 46.60 10.35 76 120386 12901 79611025
Oculomucocutaneous syndrome 46.59 10.35 18 120444 321 79623605
Dysmorphism 46.56 10.35 21 120441 560 79623366
Hepatic adenoma 46.54 10.35 18 120444 322 79623604
Bronchitis 46.08 10.35 79 120383 130565 79493361
Postictal psychosis 46.01 10.35 15 120447 158 79623768
Chest discomfort 45.54 10.35 87 120375 137957 79485969
Rash 45.45 10.35 1169 119293 577189 79046737
Hypomagnesaemia 45.43 10.35 8 120454 46903 79577023
Bruxism 45.25 10.35 42 120420 3984 79619942
Asthma-chronic obstructive pulmonary disease overlap syndrome 44.98 10.35 38 120424 3183 79620743
Obsessive-compulsive disorder 44.96 10.35 50 120412 5877 79618049
Psychomotor retardation 44.91 10.35 51 120411 6133 79617793
Contusion 44.64 10.35 99 120363 148677 79475249
Restlessness 44.51 10.35 163 120299 46329 79577597
Fluid retention 44.50 10.35 25 120437 69784 79554142
Thinking abnormal 44.47 10.35 75 120387 13086 79610840
Psychiatric symptom 44.42 10.35 54 120408 6981 79616945
Injection site erythema 44.36 10.35 32 120430 78165 79545761
Nikolsky's sign 43.89 10.35 16 120446 241 79623685
Ovarian granulosa-theca cell tumour 43.69 10.35 10 120452 21 79623905
Septic shock 43.55 10.35 74 120388 122727 79501199
Tremor 43.45 10.35 420 120042 169663 79454263
Hepatotoxicity 43.37 10.35 173 120289 51179 79572747
Hospitalisation 43.31 10.35 47 120415 94189 79529737
Shock 42.81 10.35 154 120308 43394 79580532
Disturbance in attention 42.79 10.35 171 120291 50630 79573296
Multiple sclerosis relapse 42.75 10.35 161 120301 46372 79577554
Blood alkaline phosphatase increased 42.65 10.35 200 120262 63464 79560462
Hypertension 42.44 10.35 309 120153 330683 79293243
Behaviour disorder 42.39 10.35 50 120412 6263 79617663
Hip arthroplasty 42.35 10.35 3 120459 35753 79588173
Stupor 42.18 10.35 52 120410 6820 79617106
Skin exfoliation 42.11 10.35 180 120282 54920 79569006
Constipation 41.93 10.35 630 119832 282420 79341506
Mood altered 41.90 10.35 87 120375 17760 79606166
Musculoskeletal stiffness 41.46 10.35 131 120331 174877 79449049
Cough 40.75 10.35 356 120106 366433 79257493
Paraplegia 40.71 10.35 44 120418 5009 79618917
Poisoning 40.45 10.35 106 120356 25166 79598760
Paradoxical drug reaction 40.33 10.35 52 120410 7133 79616793
Oxygen saturation decreased 40.27 10.35 84 120378 128963 79494963
Mucosal inflammation 40.24 10.35 33 120429 75547 79548379
Neutropenia 40.14 10.35 262 120200 287448 79336478
Exposure during pregnancy 40.08 10.35 276 120186 100856 79523070
Diverticulitis 40.03 10.35 10 120452 45926 79578000
Hepatocellular injury 39.92 10.35 160 120302 47433 79576493
Lymphocytosis 39.82 10.35 42 120420 4651 79619275
Cholelithiasis 39.44 10.35 171 120291 52493 79571433
Conjunctivitis 39.27 10.35 106 120356 25609 79598317
Injection site pruritus 39.27 10.35 8 120454 42275 79581651
Mental impairment 39.20 10.35 88 120374 18948 79604978
Roseolovirus test positive 38.95 10.35 14 120448 202 79623724
Histiocytosis 38.93 10.35 10 120452 40 79623886
Accidental overdose 38.93 10.35 140 120322 39441 79584485
Prostate cancer 38.81 10.35 3 120459 33265 79590661
Aspartate aminotransferase increased 38.74 10.35 349 120113 138292 79485634
Homicidal ideation 38.73 10.35 36 120426 3421 79620505
Middle insomnia 38.51 10.35 79 120383 15990 79607936
Hypotension 38.14 10.35 902 119560 439415 79184511
Autism spectrum disorder 38.12 10.35 23 120439 1129 79622797
Skin ulcer 38.11 10.35 17 120445 54133 79569793
Postictal paralysis 37.82 10.35 16 120446 364 79623562
Decreased appetite 37.75 10.35 333 120129 342085 79281841
Dehydration 37.74 10.35 220 120242 247967 79375959
Psychomotor skills impaired 37.71 10.35 43 120419 5194 79618732
Hallucination, auditory 37.51 10.35 91 120371 20602 79603324
Pain 37.39 10.35 795 119667 703007 78920919
Multiple drug therapy 37.30 10.35 38 120424 4040 79619886
Dysmetria 37.04 10.35 22 120440 1049 79622877
Epistaxis 37.02 10.35 70 120392 111445 79512481
Angiofibroma 37.02 10.35 12 120450 124 79623802
Coma scale abnormal 36.99 10.35 55 120407 8623 79615303
Epileptic psychosis 36.64 10.35 10 120452 53 79623873
Ascites 36.63 10.35 36 120426 75526 79548400
Cellulitis 36.61 10.35 68 120394 108992 79514934
Hypogammaglobulinaemia 36.29 10.35 68 120394 12883 79611043
Joint range of motion decreased 36.16 10.35 4 120458 33278 79590648
Angiomyolipoma 36.08 10.35 13 120449 189 79623737
Ill-defined disorder 36.03 10.35 28 120434 65847 79558079
Hypervolaemia 35.86 10.35 10 120452 42680 79581246
Cardiac failure 35.22 10.35 118 120344 154724 79469202
Multiple sclerosis 35.19 10.35 93 120369 22189 79601737
Rectal haemorrhage 35.12 10.35 38 120424 76262 79547664
Radiation inflammation 35.03 10.35 20 120442 885 79623041
Pleural effusion 34.92 10.35 108 120354 145154 79478772
Plasmapheresis 34.85 10.35 18 120444 651 79623275
Facial pain 34.80 10.35 65 120397 12285 79611641
Pneumonitis 34.40 10.35 25 120437 60835 79563091
Lymphocytic infiltration 34.16 10.35 24 120438 1529 79622397
Slow speech 34.12 10.35 29 120433 2449 79621477
Renal failure 33.93 10.35 172 120290 200796 79423130
Nephrogenic diabetes insipidus 33.61 10.35 27 120435 2107 79621819
Pneumonia aspiration 33.52 10.35 194 120268 66773 79557153
Abortion induced 33.13 10.35 47 120415 7062 79616864
Myalgia 33.01 10.35 156 120306 185485 79438441
Osteonecrosis of jaw 32.98 10.35 12 120450 43214 79580712
Injection site reaction 32.98 10.35 21 120441 54764 79569162
Influenza 32.86 10.35 94 120368 129512 79494414
Blood pressure increased 32.85 10.35 186 120276 211174 79412752
Bursitis 32.84 10.35 7 120455 35837 79588089
Lower respiratory tract infection 32.55 10.35 94 120368 129126 79494800
Pregnancy with implant contraceptive 32.50 10.35 25 120437 1831 79622095
Urinary tract infection 32.48 10.35 262 120200 274250 79349676
Dystonia 32.47 10.35 88 120374 21311 79602615
Adverse event 32.42 10.35 26 120436 60188 79563738
Thrombosis 32.35 10.35 48 120414 84052 79539874
Depressed mood 32.25 10.35 152 120310 48328 79575598
Dyspepsia 32.05 10.35 73 120389 108614 79515312
Palpitations 31.97 10.35 92 120370 126518 79497408
Coronary artery disease 31.96 10.35 31 120431 65443 79558483
Eosinophil count increased 31.84 10.35 76 120386 17029 79606897
Sinus arrest 31.78 10.35 33 120429 3589 79620337
Wrong patient received product 31.71 10.35 37 120425 4581 79619345
Papule 31.65 10.35 47 120415 7360 79616566
Aphasia 31.44 10.35 147 120315 46585 79577341
Amyloid arthropathy 31.35 10.35 16 120446 564 79623362
Injection site swelling 31.32 10.35 16 120446 47116 79576810
Lennox-Gastaut syndrome 31.27 10.35 12 120450 210 79623716
Unintended pregnancy 31.26 10.35 34 120428 3899 79620027
Erythema 31.13 10.35 492 119970 222798 79401128
Mental disorder 31.02 10.35 111 120351 31191 79592735
Epidermolysis bullosa 30.96 10.35 12 120450 216 79623710
Agnosia 30.96 10.35 12 120450 216 79623710
Psoriasis 30.84 10.35 55 120407 89532 79534394
Haemoglobin decreased 30.60 10.35 203 120259 221916 79402010
Osteomalacia 30.54 10.35 22 120440 1458 79622468
Seizure cluster 30.54 10.35 14 120448 388 79623538
Epileptic aura 30.14 10.35 9 120453 69 79623857
Colitis 30.03 10.35 40 120422 73267 79550659
Medication error 30.01 10.35 192 120270 68450 79555476
Posture abnormal 29.99 10.35 33 120429 3833 79620093
Musculoskeletal pain 29.98 10.35 69 120393 102285 79521641
Treatment failure 29.88 10.35 144 120318 170342 79453584
Trismus 29.80 10.35 39 120423 5428 79618498
Microcephaly 29.62 10.35 11 120451 175 79623751
Chronic kidney disease 29.29 10.35 34 120428 66120 79557806
Oedema peripheral 29.29 10.35 242 120220 252046 79371880
Rash morbilliform 29.16 10.35 41 120421 6109 79617817
Mouth ulceration 29.01 10.35 125 120337 38269 79585657
Cerebral atrophy 28.60 10.35 47 120415 8028 79615898
Oscillopsia 28.43 10.35 11 120451 197 79623729
Self esteem decreased 28.08 10.35 18 120444 984 79622942
Cerebellar atrophy 28.03 10.35 19 120443 1142 79622784
Hyperkinesia 27.87 10.35 27 120435 2702 79621224
Excessive eye blinking 27.81 10.35 22 120440 1679 79622247
Ammonia increased 27.80 10.35 45 120417 7590 79616336
Clostridium difficile infection 27.62 10.35 15 120447 42670 79581256
Blood bilirubin increased 27.58 10.35 183 120279 66049 79557877
Normal newborn 27.57 10.35 43 120419 7029 79616897
Sarcoidosis 27.50 10.35 47 120415 8288 79615638
Terminal insomnia 27.22 10.35 19 120443 1198 79622728
Muscle spasms 27.02 10.35 154 120308 174576 79449350
Drug withdrawal syndrome 26.97 10.35 114 120348 34604 79589322
Joint stiffness 26.93 10.35 14 120448 40816 79583110
Dry mouth 26.87 10.35 58 120404 87961 79535965
Personality change 26.77 10.35 52 120410 10118 79613808
Rash erythematous 26.76 10.35 164 120298 57605 79566321
Persecutory delusion 26.73 10.35 35 120427 4874 79619052
Lymphangioleiomyomatosis 26.71 10.35 10 120452 163 79623763
Neonatal pneumonia 26.68 10.35 7 120455 31 79623895
Drug withdrawal convulsions 26.59 10.35 24 120438 2196 79621730
Blood creatine phosphokinase increased 26.55 10.35 181 120281 65909 79558017
Stereotypy 26.54 10.35 17 120445 928 79622998
Neonatal hypotension 26.50 10.35 7 120455 32 79623894
Conversion disorder 26.08 10.35 22 120440 1839 79622087
Bradykinesia 26.08 10.35 45 120417 7998 79615928
Trigeminal nerve disorder 26.06 10.35 10 120452 175 79623751
Hyperexplexia 25.99 10.35 7 120455 35 79623891
Peripheral nerve decompression 25.96 10.35 8 120454 69 79623857
Mucosal ulceration 25.95 10.35 22 120440 1851 79622075
Drug level below therapeutic 25.77 10.35 50 120412 9720 79614206
Dysgeusia 25.74 10.35 29 120433 57148 79566778
Hypercalcaemia 25.61 10.35 13 120449 38417 79585509
Cerebellar ataxia 25.47 10.35 22 120440 1899 79622027
Hyperkalaemia 25.45 10.35 88 120374 114310 79509616
Dizziness 25.22 10.35 1003 119459 525438 79098488
Hepatosplenomegaly 25.20 10.35 38 120424 6031 79617895
Blood pressure fluctuation 25.17 10.35 39 120423 67106 79556820
Prominent epicanthal folds 25.14 10.35 5 120457 3 79623923
Pseudolymphoma 25.07 10.35 18 120444 1187 79622739
Acute myocardial infarction 25.01 10.35 49 120413 76987 79546939
Haematochezia 24.93 10.35 60 120402 87585 79536341
Non-24-hour sleep-wake disorder 24.92 10.35 7 120455 42 79623884
Euphoric mood 24.75 10.35 43 120419 7683 79616243
Brugada syndrome 24.63 10.35 18 120444 1220 79622706
Hypospadias 24.60 10.35 9 120453 137 79623789
Purpura 24.50 10.35 75 120387 19452 79604474
Anger 24.48 10.35 69 120393 17093 79606833
Gout 24.45 10.35 4 120458 24745 79599181
Basal cell carcinoma 24.38 10.35 13 120449 37362 79586564
Dysphagia 24.35 10.35 287 120175 121849 79502077
Mydriasis 24.26 10.35 70 120392 17573 79606353
Affect lability 24.25 10.35 53 120409 11206 79612720
Bacteriuria 24.21 10.35 18 120444 1253 79622673
Palmar-plantar erythrodysaesthesia syndrome 23.95 10.35 10 120452 33124 79590802
Memory impairment 23.82 10.35 266 120196 111468 79512458
Toxic encephalopathy 23.68 10.35 53 120409 11387 79612539
Brain malformation 23.64 10.35 7 120455 52 79623874
Genital erosion 23.52 10.35 12 120450 423 79623503
Blood osmolarity decreased 23.47 10.35 18 120444 1313 79622613
Anaphylactic reaction 23.29 10.35 58 120404 83685 79540241
Acute generalised exanthematous pustulosis 23.28 10.35 68 120394 17186 79606740
Illusion 23.21 10.35 20 120442 1721 79622205
Enanthema 23.17 10.35 15 120447 834 79623092
Cheilitis 22.98 10.35 34 120428 5307 79618619
Mitochondrial enzyme deficiency 22.98 10.35 6 120456 26 79623900
Hepatic cirrhosis 22.97 10.35 12 120450 34894 79589032
Loose associations 22.97 10.35 7 120455 58 79623868
Learning disorder 22.96 10.35 13 120449 566 79623360
Plasma cell myeloma 22.91 10.35 28 120434 53231 79570695
Abdominal distension 22.79 10.35 98 120364 119552 79504374
Acute hepatic failure 22.72 10.35 98 120364 30015 79593911
Neuromyelitis optica spectrum disorder 22.68 10.35 16 120446 1026 79622900
Respiratory disorder neonatal 22.65 10.35 7 120455 61 79623865
Poverty of speech 22.65 10.35 13 120449 581 79623345
Drug-induced liver injury 22.49 10.35 174 120288 65943 79557983
Leukocytosis 22.47 10.35 127 120335 43328 79580598
Lethargy 22.37 10.35 204 120258 81088 79542838
Eye movement disorder 22.37 10.35 42 120420 7969 79615957
Haemorrhoids 22.37 10.35 8 120454 29120 79594806
Sinus node dysfunction 22.29 10.35 41 120421 7660 79616266
Blood pressure systolic increased 22.27 10.35 42 120420 66944 79556982
Bone pain 22.24 10.35 31 120431 55711 79568215
Procedural pain 22.21 10.35 4 120458 23080 79600846
Pulmonary hypertension 22.06 10.35 24 120438 48056 79575870
Intra-abdominal pressure increased 22.05 10.35 10 120452 270 79623656
Communication disorder 22.02 10.35 29 120433 4061 79619865
Congenital inguinal hernia 22.01 10.35 5 120457 10 79623916
Opticokinetic nystagmus tests abnormal 21.99 10.35 4 120458 0 79623926
Water intoxication 21.93 10.35 14 120448 760 79623166
Vaccination site reaction 21.91 10.35 8 120454 121 79623805
Renal impairment 21.82 10.35 144 120318 157639 79466287
Therapeutic product ineffective for unapproved indication 21.81 10.35 9 120453 192 79623734
Haemorrhage 21.71 10.35 68 120394 91050 79532876
Febrile convulsion 21.70 10.35 15 120447 931 79622995
Blood immunoglobulin M decreased 21.55 10.35 17 120445 1292 79622634
Cataract 21.50 10.35 38 120424 62082 79561844
Eyelid oedema 21.49 10.35 57 120405 13630 79610296
Pulmonary arterial hypertension 21.43 10.35 8 120454 28358 79595568
Clumsiness 21.38 10.35 25 120437 3102 79620824
Metastases to liver 21.37 10.35 8 120454 28306 79595620
Nasal congestion 21.31 10.35 53 120409 76499 79547427
Gingival hypertrophy 21.29 10.35 25 120437 3117 79620809
Blood sodium decreased 21.20 10.35 103 120359 33152 79590774
Gingival atrophy 21.20 10.35 7 120455 77 79623849
Cardiac disorder 21.19 10.35 42 120420 65715 79558211
Nasal polyps 21.19 10.35 39 120423 7288 79616638
Hyperpyrexia 20.96 10.35 35 120427 6057 79617869
Developmental regression 20.82 10.35 6 120456 40 79623886
Night sweats 20.76 10.35 29 120433 52066 79571860
Abortion spontaneous 20.72 10.35 94 120368 29413 79594513
Pulmonary mass 20.61 10.35 9 120453 29025 79594901
Photophobia 20.52 10.35 73 120389 20455 79603471
Sputum discoloured 20.43 10.35 4 120458 21739 79602187
B-lymphocyte count decreased 20.40 10.35 17 120445 1397 79622529
Retinal deposits 20.39 10.35 8 120454 149 79623777
Product complaint 20.36 10.35 55 120407 13294 79610632
Rhesus incompatibility 20.33 10.35 5 120457 16 79623910
Central nervous system lesion 20.31 10.35 55 120407 13313 79610613
Condition aggravated 20.23 10.35 938 119524 500186 79123740
Ultrasound ovary abnormal 20.21 10.35 7 120455 90 79623836
Immune thrombocytopenia 20.15 10.35 66 120396 17739 79606187
Disorientation 20.14 10.35 163 120299 62613 79561313
Fungal infection 20.10 10.35 20 120442 41728 79582198
Selective IgG subclass deficiency 20.10 10.35 5 120457 17 79623909
Salivary hypersecretion 20.10 10.35 57 120405 14167 79609759
Dyspnoea exertional 20.04 10.35 66 120396 87007 79536919
Device expulsion 20.04 10.35 7 120455 25854 79598072
Withdrawal syndrome 19.95 10.35 87 120375 26767 79597159
Ejection fraction decreased 19.81 10.35 14 120448 34563 79589363
Tracheo-oesophageal fistula 19.80 10.35 12 120450 594 79623332
Catatonia 19.76 10.35 42 120420 8714 79615212
Dexamethasone suppression test positive 19.75 10.35 4 120458 3 79623923
Brain lobectomy 19.75 10.35 4 120458 3 79623923
Frequent bowel movements 19.67 10.35 10 120452 29529 79594397
Brain oedema 19.66 10.35 83 120379 25180 79598746
Bladder cancer 19.64 10.35 3 120459 19523 79604403
Potentiating drug interaction 19.55 10.35 42 120420 8777 79615149
Full blood count decreased 19.54 10.35 8 120454 26811 79597115
Convulsive threshold lowered 19.37 10.35 14 120448 933 79622993
Injection site bruising 19.34 10.35 20 120442 40982 79582944
Respiratory arrest 19.32 10.35 151 120311 57399 79566527
Anaemia megaloblastic 19.28 10.35 12 120450 623 79623303
Adverse drug reaction 19.24 10.35 45 120417 66347 79557579
Confusional state 19.17 10.35 622 119840 317375 79306551
Red blood cell sedimentation rate increased 18.88 10.35 25 120437 45917 79578009
Affective disorder 18.88 10.35 40 120422 8279 79615647
COVID-19 pneumonia 18.86 10.35 10 120452 28839 79595087
Urinary incontinence 18.86 10.35 116 120346 40793 79583133
Gastroenteritis viral 18.76 10.35 7 120455 24824 79599102
Candida infection 18.76 10.35 18 120444 38196 79585730
Perseveration 18.74 10.35 10 120452 387 79623539
Blood hyposmosis 18.73 10.35 5 120457 24 79623902
Fabry's disease 18.73 10.35 5 120457 24 79623902
Incoherent 18.65 10.35 38 120424 7654 79616272
Measles 18.65 10.35 10 120452 391 79623535
Atrioventricular block 18.62 10.35 55 120407 13986 79609940
Hyperdynamic left ventricle 18.60 10.35 10 120452 393 79623533
Cardiac arrest 18.53 10.35 364 120098 171732 79452194
Fanconi syndrome 18.16 10.35 22 120440 2834 79621092
Dermatitis bullous 18.14 10.35 55 120407 14190 79609736
Abortion threatened 18.10 10.35 10 120452 415 79623511
Polydipsia psychogenic 17.99 10.35 8 120454 206 79623720
Transfusion 17.91 10.35 5 120457 21325 79602601
Hyperthermia 17.91 10.35 64 120398 17973 79605953
Diabetic neuropathy 17.87 10.35 33 120429 6183 79617743
Emotional disorder 17.81 10.35 55 120407 14332 79609594
Right ventricular dilatation 17.71 10.35 18 120444 1908 79622018
Fulminant type 1 diabetes mellitus 17.70 10.35 16 120446 1467 79622459
Logorrhoea 17.66 10.35 27 120435 4338 79619588
Hyperprolactinaemia 17.63 10.35 28 120434 4648 79619278
Therapy interrupted 17.55 10.35 13 120449 31328 79592598
Pneumocystis jirovecii pneumonia 17.54 10.35 14 120448 32494 79591432
Genital ulceration 17.50 10.35 14 120448 1086 79622840
Unevaluable event 17.49 10.35 36 120426 55549 79568377
Rickets 17.48 10.35 6 120456 75 79623851
Eosinophilic oesophagitis 17.47 10.35 11 120451 583 79623343
Unresponsive to stimuli 17.44 10.35 144 120318 55644 79568282
Bipolar disorder 17.43 10.35 37 120425 7670 79616256
Transplant rejection 17.39 10.35 4 120458 19433 79604493
Epidermal necrosis 17.39 10.35 16 120446 1501 79622425
Thrombocytopenic purpura 17.32 10.35 20 120442 2449 79621477
Derailment 17.26 10.35 6 120456 78 79623848
Herpes zoster 17.26 10.35 77 120385 93006 79530920
Benzodiazepine drug level increased 17.24 10.35 8 120454 228 79623698
Lactate pyruvate ratio increased 17.20 10.35 6 120456 79 79623847
Labelled drug-drug interaction medication error 17.17 10.35 85 120377 27565 79596361
Mitral valve incompetence 17.12 10.35 11 120451 28554 79595372
Oedema 17.11 10.35 108 120354 119472 79504454
Wrong technique in product usage process 17.00 10.35 56 120406 73819 79550107
Inappropriate schedule of product administration 16.98 10.35 125 120337 133503 79490423
Conjunctival oedema 16.87 10.35 14 120448 1144 79622782
Muscle rigidity 16.80 10.35 67 120395 19815 79604111
Feeling of despair 16.76 10.35 21 120441 2800 79621126
Paresis 16.74 10.35 26 120436 4235 79619691
Extensor plantar response 16.71 10.35 17 120445 1804 79622122
Areflexia 16.70 10.35 30 120432 5504 79618422
Chills 16.68 10.35 158 120304 160076 79463850
Cytomegalovirus mucocutaneous ulcer 16.67 10.35 6 120456 87 79623839
Bacteraemia 16.66 10.35 15 120447 32809 79591117
Pleural neoplasm 16.62 10.35 9 120453 359 79623567
Suspiciousness 16.61 10.35 11 120451 636 79623290
Scab 16.57 10.35 44 120418 10528 79613398
Nodule 16.53 10.35 7 120455 22987 79600939
Drug level above therapeutic 16.50 10.35 39 120423 8684 79615242
SUNCT syndrome 16.49 10.35 3 120459 0 79623926
Tensilon test abnormal 16.49 10.35 3 120459 0 79623926
Urticaria vesiculosa 16.46 10.35 4 120458 12 79623914
Malaise 16.44 10.35 590 119872 489279 79134647
Hepatitis 16.44 10.35 142 120320 55585 79568341
Bradycardia 16.42 10.35 292 120170 135265 79488661
Carcinoembryonic antigen 16.36 10.35 6 120456 92 79623834
Nephrolithiasis 16.36 10.35 35 120427 53256 79570670
Petechiae 16.34 10.35 68 120394 20497 79603429
Foot deformity 16.26 10.35 8 120454 24066 79599860
Vaginal erosion 16.22 10.35 4 120458 13 79623913
Carbohydrate antigen 15-3 16.18 10.35 6 120456 95 79623831
Pulmonary fibrosis 16.17 10.35 26 120436 44086 79579840
Drowning 16.17 10.35 12 120450 833 79623093
Encephalocele 16.14 10.35 5 120457 44 79623882
Tumour lysis syndrome 16.10 10.35 8 120454 23931 79599995
Clostridium difficile colitis 16.09 10.35 15 120447 32268 79591658
Hot flush 16.06 10.35 37 120425 54840 79569086
Vaginal ulceration 15.97 10.35 8 120454 271 79623655
Low set ears 15.90 10.35 6 120456 100 79623826
Hallucination, visual 15.85 10.35 94 120368 32635 79591291
Tic 15.81 10.35 21 120441 2965 79620961
Subacute cutaneous lupus erythematosus 15.80 10.35 23 120439 3538 79620388
Right ventricular failure 15.58 10.35 8 120454 23489 79600437
Ultrasound liver abnormal 15.58 10.35 7 120455 185 79623741
Cholestasis 15.49 10.35 133 120329 51976 79571950
Drug dependence 15.40 10.35 110 120352 40659 79583267
Sensory disturbance 15.40 10.35 54 120408 15023 79608903
Upper respiratory tract infection 15.39 10.35 78 120384 91090 79532836
Therapeutic product effective for unapproved indication 15.38 10.35 6 120456 110 79623816
Vitamin D deficiency 15.33 10.35 52 120410 14227 79609699
Dry skin 15.33 10.35 52 120410 67943 79555983
Cranial nerve disorder 15.30 10.35 13 120449 1097 79622829
Polydipsia 15.27 10.35 32 120430 6573 79617353
Oral mucosal eruption 15.26 10.35 11 120451 730 79623196
Colitis ulcerative 15.23 10.35 18 120444 34724 79589202
Distractibility 15.20 10.35 11 120451 734 79623192
Neurosis 15.17 10.35 9 120453 428 79623498
Encephalopathy 15.07 10.35 162 120300 67235 79556691
Weight increased 15.05 10.35 312 120150 277074 79346852
SJS-TEN overlap 15.02 10.35 11 120451 748 79623178
Learning disability 14.98 10.35 7 120455 203 79623723
Lip ulceration 14.93 10.35 18 120444 2307 79621619
Idiopathic generalised epilepsy 14.90 10.35 5 120457 58 79623868
Hypothermia 14.90 10.35 71 120391 22675 79601251
Ulcer 14.85 10.35 14 120448 29958 79593968
Cytomegalovirus infection 14.83 10.35 26 120436 42618 79581308
Blood citric acid increased 14.83 10.35 5 120457 59 79623867
Peripheral venous disease 14.79 10.35 3 120459 15906 79608020
Sciatica 14.79 10.35 17 120445 33205 79590721
Depressive symptom 14.71 10.35 31 120431 6392 79617534
Frontotemporal dementia 14.69 10.35 10 120452 605 79623321
Hangover 14.63 10.35 17 120445 2095 79621831
Disorganised speech 14.60 10.35 17 120445 2100 79621826
Negative thoughts 14.59 10.35 14 120448 1385 79622541
Hypomania 14.56 10.35 34 120428 7510 79616416
Visual field defect 14.54 10.35 38 120424 9007 79614919
Pericardial effusion 14.50 10.35 30 120432 46207 79577719
Acute respiratory failure 14.49 10.35 44 120418 59497 79564429
Paranoia 14.47 10.35 63 120399 19369 79604557
Human herpesvirus 7 infection 14.45 10.35 6 120456 130 79623796
Macule 14.45 10.35 20 120442 2937 79620989
Hypoglycaemia 14.41 10.35 92 120370 101502 79522424
Sinus disorder 14.38 10.35 8 120454 22456 79601470
Priapism 14.34 10.35 25 120437 4480 79619446
Angina pectoris 14.25 10.35 36 120426 51696 79572230
Neoplasm progression 14.21 10.35 36 120426 51646 79572280
Skin lesion 14.16 10.35 110 120352 41734 79582192
Developmental delay 14.14 10.35 13 120449 1218 79622708
Migraine 14.13 10.35 76 120386 87417 79536509
Epileptic encephalopathy 14.12 10.35 9 120453 487 79623439
Melaena 14.11 10.35 46 120416 60844 79563082
Wrong dose 14.09 10.35 15 120447 1679 79622247
Antipsychotic drug level below therapeutic 14.08 10.35 13 120449 1225 79622701
Screaming 14.08 10.35 23 120439 3910 79620016
Liver function test increased 14.06 10.35 24 120438 39749 79584177
Loss of personal independence in daily activities 13.99 10.35 94 120368 102486 79521440
Tooth development disorder 13.99 10.35 5 120457 71 79623855
Joint injury 13.98 10.35 16 120446 31319 79592607
Bundle branch block right 13.91 10.35 43 120419 11208 79612718
Red cell distribution width increased 13.91 10.35 3 120459 15239 79608687
Therapy cessation 13.90 10.35 22 120440 37540 79586386
Vision blurred 13.87 10.35 231 120231 105667 79518259
Respiratory depression 13.79 10.35 80 120382 27550 79596376
Gastric disorder 13.78 10.35 22 120440 37411 79586515
Rash pustular 13.78 10.35 43 120419 11268 79612658
Bone metabolism disorder 13.77 10.35 9 120453 509 79623417
Guillain-Barre syndrome 13.73 10.35 37 120425 8928 79614998
Congenital arterial malformation 13.71 10.35 4 120458 28 79623898
Blood immunoglobulin G decreased 13.67 10.35 21 120441 3388 79620538
Pyroglutamate increased 13.54 10.35 10 120452 689 79623237
Gastrooesophageal reflux disease 13.49 10.35 97 120365 104149 79519777
Diverticulum 13.46 10.35 3 120459 14893 79609033
Rhinitis allergic 13.46 10.35 45 120417 12224 79611702
Juvenile myoclonic epilepsy 13.44 10.35 5 120457 80 79623846
Hypoxia 13.39 10.35 96 120366 103147 79520779
Blood test abnormal 13.37 10.35 5 120457 17705 79606221
Treatment noncompliance 13.30 10.35 129 120333 52139 79571787
Blood creatinine increased 13.27 10.35 160 120302 154897 79469029
Antisocial behaviour 13.26 10.35 10 120452 711 79623215
Inhibitory drug interaction 13.26 10.35 24 120438 4429 79619497
Paralogism 13.25 10.35 4 120458 32 79623894
Drug half-life reduced 13.20 10.35 3 120459 6 79623920
Apgar score low 13.20 10.35 3 120459 6 79623920
Thrombotic microangiopathy 13.17 10.35 7 120455 20162 79603764
Pyuria 13.17 10.35 17 120445 2335 79621591
Flatulence 13.16 10.35 28 120434 42696 79581230
Lower gastrointestinal haemorrhage 13.13 10.35 4 120458 16121 79607805
Xanthelasma 13.13 10.35 6 120456 165 79623761
Sluggishness 13.11 10.35 30 120432 6542 79617384
Obsessive thoughts 13.09 10.35 12 120450 1120 79622806
Staring 13.09 10.35 18 120444 2627 79621299
Pancytopenia 13.08 10.35 174 120288 165571 79458355
Infrapatellar fat pad inflammation 13.06 10.35 6 120456 167 79623759
Coagulation time shortened 13.05 10.35 8 120454 404 79623522
Device issue 13.04 10.35 13 120449 27095 79596831
Rheumatoid nodule 13.04 10.35 5 120457 17433 79606493
Medulloblastoma 13.00 10.35 5 120457 88 79623838
Localised infection 12.99 10.35 23 120439 37552 79586374
Drug level changed 12.91 10.35 9 120453 566 79623360
Agranulocytosis 12.90 10.35 114 120348 44916 79579010
Caesarean section 12.89 10.35 45 120417 12490 79611436
Bipolar I disorder 12.89 10.35 16 120446 2113 79621813
Sinus congestion 12.86 10.35 7 120455 19889 79604037
Diabetes insipidus 12.85 10.35 26 120436 5211 79618715
Therapeutic response shortened 12.80 10.35 4 120458 15859 79608067
Intentional product misuse to child 12.80 10.35 5 120457 92 79623834
Device related infection 12.77 10.35 20 120442 34274 79589652
Thyroid adenoma 12.77 10.35 6 120456 176 79623750
Second primary malignancy 12.75 10.35 3 120459 14347 79609579
Pigmentation disorder 12.74 10.35 27 120435 5591 79618335
Illiteracy 12.73 10.35 4 120458 37 79623889
Dry age-related macular degeneration 12.73 10.35 7 120455 288 79623638
Intervertebral disc degeneration 12.71 10.35 4 120458 15781 79608145
Wrong drug 12.70 10.35 7 120455 289 79623637
Disability 12.65 10.35 5 120457 17115 79606811
Abortion 12.65 10.35 13 120449 1397 79622529
Wrong product administered 12.62 10.35 36 120426 8976 79614950
Granulocytopenia 12.60 10.35 42 120420 11389 79612537
Muscle twitching 12.56 10.35 72 120390 24692 79599234
Eye discharge 12.54 10.35 28 120434 6006 79617920
Glycosuria 12.54 10.35 16 120446 2172 79621754
Pupillary reflex impaired 12.53 10.35 20 120442 3333 79620593
Lower limb fracture 12.52 10.35 10 120452 23205 79600721
Cardiomyopathy 12.51 10.35 15 120447 28759 79595167
Squamous cell carcinoma 12.50 10.35 4 120458 15618 79608308
Automatism 12.50 10.35 6 120456 185 79623741
Throat irritation 12.48 10.35 27 120435 40919 79583007
Appendicitis 12.47 10.35 8 120454 20786 79603140
Gastric hypomotility 12.47 10.35 6 120456 186 79623740
Niemann-Pick disease 12.46 10.35 4 120458 40 79623886
Open angle glaucoma 12.45 10.35 8 120454 439 79623487
Hypersexuality 12.45 10.35 14 120448 1666 79622260
Neurotoxicity 12.44 10.35 88 120374 32430 79591496
Maternal drugs affecting foetus 12.43 10.35 14 120448 1669 79622257
Pseudophaeochromocytoma 12.37 10.35 5 120457 101 79623825
Crying 12.35 10.35 68 120394 22975 79600951
Grip strength decreased 12.34 10.35 9 120453 21860 79602066
Drug ineffective 12.32 10.35 1836 118626 1079077 78544849
Bone marrow failure 12.27 10.35 38 120424 51069 79572857
Hypochloraemia 12.27 10.35 17 120445 2498 79621428
Product dispensing error 12.27 10.35 46 120416 13217 79610709
Biopsy skin abnormal 12.26 10.35 6 120456 193 79623733
Low birth weight baby 12.26 10.35 9 120453 614 79623312
Impaired driving ability 12.25 10.35 26 120436 5389 79618537
Onychophagia 12.19 10.35 5 120457 105 79623821
Injury 12.14 10.35 68 120394 77428 79546498
Tonic clonic movements 12.11 10.35 16 120446 2248 79621678
Hyperglycinaemia 12.11 10.35 3 120459 10 79623916
Selective IgA immunodeficiency 12.11 10.35 3 120459 10 79623916
Injection site rash 12.07 10.35 6 120456 17948 79605978
Blood pressure diastolic abnormal 12.06 10.35 7 120455 19195 79604731
Iliac artery occlusion 12.05 10.35 7 120455 320 79623606
Nephropathy toxic 12.05 10.35 8 120454 20411 79603515
Skin oedema 12.04 10.35 14 120448 1727 79622199
Genital burning sensation 12.03 10.35 7 120455 321 79623605
Glomerular filtration rate decreased 11.97 10.35 10 120452 22692 79601234
Tuberculosis 11.97 10.35 4 120458 15194 79608732
Tendonitis 11.96 10.35 11 120451 23819 79600107
Heart rate decreased 11.96 10.35 60 120402 70256 79553670
Feeling hot 11.94 10.35 48 120414 59686 79564240
Odynophagia 11.94 10.35 41 120421 11286 79612640
Neutropenic sepsis 11.88 10.35 14 120448 27050 79596876
Device dislocation 11.88 10.35 13 120449 25957 79597969
Renal phospholipidosis 11.85 10.35 5 120457 113 79623813
Atelectasis 11.84 10.35 19 120443 32238 79591688
Impulsive behaviour 11.82 10.35 18 120444 2882 79621044
Encapsulating peritoneal sclerosis 11.80 10.35 10 120452 841 79623085
Peritonitis 11.79 10.35 15 120447 28021 79595905
Conjunctival disorder 11.78 10.35 7 120455 334 79623592
Mucosal disorder 11.78 10.35 20 120442 3508 79620418
Rhinorrhoea 11.78 10.35 67 120395 76007 79547919
Parkinsonism 11.77 10.35 53 120409 16531 79607395
Major depression 11.74 10.35 35 120427 8945 79614981
Hepatomegaly 11.70 10.35 58 120404 18816 79605110
Dissociative amnesia 11.69 10.35 5 120457 117 79623809
Biopsy lymph gland abnormal 11.68 10.35 3 120459 12 79623914
Hypoosmolar state 11.67 10.35 7 120455 340 79623586
Near drowning 11.65 10.35 4 120458 50 79623876
Acanthosis 11.65 10.35 8 120454 491 79623435
Injection site haemorrhage 11.62 10.35 15 120447 27855 79596071
Neuropsychiatric syndrome 11.61 10.35 5 120457 119 79623807
Necrosis ischaemic 11.54 10.35 11 120451 1079 79622847
Pulmonary embolism 11.53 10.35 186 120276 171468 79452458
Speech disorder developmental 11.51 10.35 9 120453 675 79623251
Cardio-respiratory arrest 11.50 10.35 229 120233 108281 79515645
Ischaemic gastritis 11.49 10.35 3 120459 13 79623913
Angiosclerosis 11.49 10.35 3 120459 13 79623913
Disseminated intravascular coagulation 11.46 10.35 93 120369 35749 79588177
Pneumatosis 11.42 10.35 10 120452 879 79623047
Sensorimotor disorder 11.37 10.35 10 120452 884 79623042
Type 2 diabetes mellitus 11.36 10.35 46 120416 57076 79566850
Carnitine decreased 11.31 10.35 3 120459 14 79623912
Conjunctival discolouration 11.27 10.35 5 120457 128 79623798
Tricuspid valve incompetence 11.27 10.35 8 120454 19704 79604222
Colectomy total 11.24 10.35 7 120455 364 79623562
Acid base balance abnormal 11.22 10.35 7 120455 365 79623561
Tetany 11.21 10.35 17 120445 2711 79621215
Ileus paralytic 11.19 10.35 36 120426 9584 79614342
Patient uncooperative 11.17 10.35 9 120453 705 79623221
Hepatitis fulminant 11.15 10.35 30 120432 7232 79616694
Enlarged cerebral perivascular spaces 11.14 10.35 3 120459 15 79623911
Myelosuppression 11.13 10.35 28 120434 40268 79583658
Vestibular disorder 11.10 10.35 16 120446 2439 79621487
Nervous system disorder 11.05 10.35 74 120388 26782 79597144
Oral disorder 11.05 10.35 37 120425 10058 79613868
Deep vein thrombosis 11.04 10.35 123 120339 120796 79503130
Hypoproteinaemia 11.03 10.35 21 120441 4025 79619901
Febrile bone marrow aplasia 11.03 10.35 3 120459 13017 79610909
Respiratory disorder 11.02 10.35 33 120429 44823 79579103
Histiocytic necrotising lymphadenitis 10.99 10.35 4 120458 60 79623866
Congenital anomaly 10.98 10.35 7 120455 379 79623547
Wound infection 10.98 10.35 12 120450 23979 79599947
Myelodysplastic syndrome 10.98 10.35 18 120444 30283 79593643
Anaplastic large cell lymphoma T- and null-cell types 10.93 10.35 5 120457 138 79623788
Lip swelling 10.92 10.35 102 120360 40809 79583117
Tardive dyskinesia 10.92 10.35 38 120424 10533 79613393
Pathogen resistance 10.91 10.35 4 120458 14338 79609588
Head injury 10.91 10.35 95 120367 37274 79586652
Pulmonary toxicity 10.89 10.35 3 120459 12911 79611015
Enterococcal infection 10.89 10.35 5 120457 15655 79608271
Blood glucose increased 10.87 10.35 116 120346 114859 79509067
Poor venous access 10.86 10.35 7 120455 18142 79605784
Effusion 10.86 10.35 15 120447 2199 79621727
Hyperacusis 10.81 10.35 15 120447 2208 79621718
Cardiac murmur 10.81 10.35 50 120412 15774 79608152
Sitting disability 10.80 10.35 7 120455 390 79623536
Altered visual depth perception 10.80 10.35 7 120455 390 79623536
Dementia 10.79 10.35 69 120393 24590 79599336
Maculopathy 10.77 10.35 17 120445 2808 79621118
Uveitis 10.76 10.35 6 120456 16824 79607102
Lymphopenia 10.72 10.35 81 120381 30476 79593450
Infusion site pain 10.70 10.35 4 120458 14172 79609754
Basilar migraine 10.69 10.35 4 120458 65 79623861
Growth hormone-producing pituitary tumour 10.69 10.35 4 120458 65 79623861
Acinetobacter test positive 10.69 10.35 6 120456 257 79623669
Breath odour 10.68 10.35 13 120449 1683 79622243
Salivary gland calculus 10.64 10.35 6 120456 259 79623667
Human herpesvirus 6 infection reactivation 10.63 10.35 8 120454 567 79623359
Gastric ulcer 10.63 10.35 22 120440 33883 79590043
Pain in jaw 10.60 10.35 35 120427 46116 79577810
Mitochondrial cytopathy 10.60 10.35 7 120455 403 79623523
Sperm concentration decreased 10.58 10.35 4 120458 67 79623859
Anticonvulsant drug level abnormal 10.58 10.35 4 120458 67 79623859
Trigemino-cardiac reflex 10.56 10.35 6 120456 263 79623663
Erythema of eyelid 10.54 10.35 16 120446 2554 79621372
Educational problem 10.53 10.35 7 120455 407 79623519
Squamous cell carcinoma of skin 10.53 10.35 4 120458 14029 79609897
Breast cancer 10.52 10.35 22 120440 33759 79590167
Liver function test abnormal 10.51 10.35 146 120316 64329 79559597
Respiratory tract infection 10.46 10.35 38 120424 48651 79575275
Hyperbilirubinaemia 10.43 10.35 13 120449 24505 79599421
Eyelid erosion 10.42 10.35 4 120458 70 79623856
Lung disorder 10.40 10.35 75 120387 80482 79543444
Stab wound 10.40 10.35 6 120456 271 79623655
Mycoplasma infection 10.39 10.35 9 120453 780 79623146

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N03AF01 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Carboxamide derivatives
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
CHEBI has role CHEBI:35477 antimanic drugs
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:38633 sodium channel blockers
CHEBI has role CHEBI:52290 mitogens
CHEBI has role CHEBI:61115 histone deacetylase inhibitors
CHEBI has role CHEBI:64370 glutamate transporter activators
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:88188 allergenic drug
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000927 Anticonvulsants
MeSH PA D018692 Antimanic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D065701 Cytochrome P-450 CYP3A Inducers
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018689 Sensory System Agents
MeSH PA D026941 Sodium Channel Blockers
MeSH PA D014149 Tranquilizing Agents
FDA EPC N0000175751 Mood Stabilizer
FDA MoA N0000185506 Cytochrome P450 3A4 Inducers
FDA MoA N0000185507 Cytochrome P450 2C9 Inducers
FDA MoA N0000185607 Cytochrome P450 2C19 Inducers
FDA MoA N0000187064 Cytochrome P450 2B6 Inducers
FDA MoA N0000191266 Cytochrome P450 1A2 Inducers

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Mixed bipolar I disorder indication 16506000 DOID:3312
Trigeminal neuralgia indication 31681005 DOID:12098
Glossopharyngeal neuralgia indication 43763009 DOID:14423
Tonic-clonic seizure indication 54200006
Epilepsy indication 84757009 DOID:1826
Bipolar disorder in remission indication 85248005
Bipolar affective disorder, current episode manic indication 191618007
Localization-related epilepsy indication 230381009 DOID:2234
Lennox-Gastaut syndrome indication 230418006
Tonic-clonic epilepsy indication 352818000 DOID:7725
Epilepsy characterized by intractable complex partial seizures indication 442481002
Simple partial seizure indication 117891000119100
Mixed Epilepsy indication
Neurohypophyseal diabetes insipidus off-label use 45369008 DOID:12388
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Neuropathic pain off-label use 247398009
Attention deficit hyperactivity disorder off-label use 406506008
Prevention of Seizures following Cranial Trauma or Surgery off-label use
Rapid Cycling Bipolar Affective Disorder off-label use
Ocular hypertension contraindication 4210003 DOID:9282
Suicidal thoughts contraindication 6471006
Hypercholesterolemia contraindication 13644009
Agranulocytosis contraindication 17182001 DOID:12987
Mood swings contraindication 18963009
Glaucoma contraindication 23986001 DOID:1686
Complete atrioventricular block contraindication 27885002
Depressive disorder contraindication 35489007
Hypertensive disorder contraindication 38341003 DOID:10763
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Acute nephropathy contraindication 58574008
Absence seizure contraindication 79631006
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Pancytopenia contraindication 127034005 DOID:12450
Impaired renal function disorder contraindication 197663003
Non-infective meningitis contraindication 230155003
Acute intermittent porphyria contraindication 234422006 DOID:3890
Disease of liver contraindication 235856003 DOID:409
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Aplastic anemia contraindication 306058006 DOID:12449
Bone marrow depression contraindication 307762000
Disorder of coronary artery contraindication 414024009
HLA-B 1502 Positive Status contraindication
Carbamazepine Toxicity contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.13 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
100MG EQUETRO VALIDUS PHARMS N021710 Dec. 10, 2004 RX CAPSULE, EXTENDED RELEASE ORAL 6977253 May 19, 2024 THE RECOMMENDED INITIAL DOSE OF EQUETRO IS 400MG/DAY GIVEN IN DIVIDED DOSES, TWICE DAILY. THE DOSE SHOULD BE ADJUSTED IN 200MG DAILY INCREMENTS TO ACHIEVE OPTIMAL CLINICAL RESPONSE.
200MG EQUETRO VALIDUS PHARMS N021710 Dec. 10, 2004 RX CAPSULE, EXTENDED RELEASE ORAL 6977253 May 19, 2024 THE RECOMMENDED INITIAL DOSE OF EQUETRO IS 400MG/DAY GIVEN IN DIVIDED DOSES, TWICE DAILY. THE DOSE SHOULD BE ADJUSTED IN 200MG DAILY INCREMENTS TO ACHIEVE OPTIMAL CLINICAL RESPONSE.
300MG EQUETRO VALIDUS PHARMS N021710 Dec. 10, 2004 RX CAPSULE, EXTENDED RELEASE ORAL 6977253 May 19, 2024 THE RECOMMENDED INITIAL DOSE OF EQUETRO IS 400MG/DAY GIVEN IN DIVIDED DOSES, TWICE DAILY. THE DOSE SHOULD BE ADJUSTED IN 200MG DAILY INCREMENTS TO ACHIEVE OPTIMAL CLINICAL RESPONSE.
200MG/20ML (10MG/ML) CARNEXIV LUNDBECK PHARMS LLC N206030 Oct. 7, 2016 DISCN SOLUTION INTRAVENOUS 9629797 Nov. 10, 2028 REPLACEMENT THERAPY FOR ORAL CARBAMAZEPINE IN ADULTS WITH GENERALIZED TONIC-CLONIC SEIZURES
200MG/20ML (10MG/ML) CARNEXIV LUNDBECK PHARMS LLC N206030 Oct. 7, 2016 DISCN SOLUTION INTRAVENOUS 9629797 Nov. 10, 2028 REPLACEMENT THERAPY FOR ORAL CARBAMAZEPINE IN ADULTS WITH MIXED SEIZURE PATTERNS THAT INCLUDE PARTIAL SEIZURES WITH COMPLEX SYMPTOMATOLOGY, GENERALIZED TONIC-CLONIC SEIZURES, OR OTHER PARTIAL OR GENERALIZED SEIZURES
200MG/20ML (10MG/ML) CARNEXIV LUNDBECK PHARMS LLC N206030 Oct. 7, 2016 DISCN SOLUTION INTRAVENOUS 9629797 Nov. 10, 2028 REPLACEMENT THERAPY FOR ORAL CARBAMAZEPINE IN ADULTS WITH PARTIAL SEIZURES WITH COMPLEX SYMPTOMATOLOGY

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
200MG/20ML (10MG/ML) CARNEXIV LUNDBECK PHARMS LLC N206030 Oct. 7, 2016 DISCN SOLUTION INTRAVENOUS Oct. 7, 2023 REPLACEMENT THERAPY FOR ORAL CARBAMAZEPINE FORMULATIONS, WHEN ORAL ADMINISTRATION IS TEMPORARILY NOT FEASIBLE, IN ADULTS WITH THE FOLLOWING SEIZURE TYPES: PARTIAL WITH COMPLEX SYMPTOMOLOGY, GENERALIZED CLONIC-TONIC, AND MIXED

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium channel protein type 4 subunit alpha Ion channel BLOCKER Ki 4.28 CHEMBL CHEMBL
Sodium channel protein type 9 subunit alpha Ion channel BLOCKER IC50 4.66 CHEMBL CHEMBL
Sodium channel protein type 5 subunit alpha Ion channel BLOCKER WOMBAT-PK CHEMBL
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor WOMBAT-PK
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel WOMBAT-PK
Neuronal acetylcholine receptor; alpha2/beta4 Ion channel IC50 4.31 WOMBAT-PK
Frizzled-8 GPCR ALLOSTERIC MODULATOR Kd 4.77 IUPHAR
Sodium-dependent serotonin transporter Transporter Kd 4.50 WOMBAT-PK
Histamine H1 receptor GPCR Ki 4.13 WOMBAT-PK
Frizzled-8 GPCR Kd 4.78 CHEMBL

External reference:

IDSource
4017873 VUID
N0000146226 NUI
D00252 KEGG_DRUG
2002 RXNORM
C0006949 UMLSCUI
CHEBI:3387 CHEBI
N6W PDB_CHEM_ID
CHEMBL108 ChEMBL_ID
DB00564 DRUGBANK_ID
D002220 MESH_DESCRIPTOR_UI
2554 PUBCHEM_CID
5339 IUPHAR_LIGAND_ID
1836 INN_ID
85756-57-6 SECONDARY_CAS_RN
33CM23913M UNII
4350 MMSL
513 MMSL
d00058 MMSL
387222003 SNOMEDCT_US
40820003 SNOMEDCT_US
4017873 VANDF
001634 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Tegretol HUMAN PRESCRIPTION DRUG LABEL 1 0078-0508 SUSPENSION 100 mg ORAL NDA 27 sections
Tegretol HUMAN PRESCRIPTION DRUG LABEL 1 0078-0508 SUSPENSION 100 mg ORAL NDA 27 sections
Tegretol HUMAN PRESCRIPTION DRUG LABEL 1 0078-0508 SUSPENSION 100 mg ORAL NDA 27 sections
Tegretol HUMAN PRESCRIPTION DRUG LABEL 1 0078-0509 TABLET 200 mg ORAL NDA 27 sections
Tegretol HUMAN PRESCRIPTION DRUG LABEL 1 0078-0509 TABLET 200 mg ORAL NDA 27 sections
Tegretol HUMAN PRESCRIPTION DRUG LABEL 1 0078-0509 TABLET 200 mg ORAL NDA 27 sections
TegretolXR HUMAN PRESCRIPTION DRUG LABEL 1 0078-0510 TABLET, EXTENDED RELEASE 100 mg ORAL NDA 27 sections
TegretolXR HUMAN PRESCRIPTION DRUG LABEL 1 0078-0510 TABLET, EXTENDED RELEASE 100 mg ORAL NDA 27 sections
TegretolXR HUMAN PRESCRIPTION DRUG LABEL 1 0078-0510 TABLET, EXTENDED RELEASE 100 mg ORAL NDA 27 sections
TegretolXR HUMAN PRESCRIPTION DRUG LABEL 1 0078-0511 TABLET, EXTENDED RELEASE 200 mg ORAL NDA 27 sections
TegretolXR HUMAN PRESCRIPTION DRUG LABEL 1 0078-0511 TABLET, EXTENDED RELEASE 200 mg ORAL NDA 27 sections
TegretolXR HUMAN PRESCRIPTION DRUG LABEL 1 0078-0511 TABLET, EXTENDED RELEASE 200 mg ORAL NDA 27 sections
TegretolXR HUMAN PRESCRIPTION DRUG LABEL 1 0078-0512 TABLET, EXTENDED RELEASE 400 mg ORAL NDA 27 sections
TegretolXR HUMAN PRESCRIPTION DRUG LABEL 1 0078-0512 TABLET, EXTENDED RELEASE 400 mg ORAL NDA 27 sections
TegretolXR HUMAN PRESCRIPTION DRUG LABEL 1 0078-0512 TABLET, EXTENDED RELEASE 400 mg ORAL NDA 27 sections
Epitol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0090 TABLET 200 mg ORAL ANDA 27 sections
Epitol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0090 TABLET 200 mg ORAL ANDA 27 sections
Carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 0093-0109 TABLET 200 mg ORAL ANDA 27 sections
Carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 0093-0109 TABLET 200 mg ORAL ANDA 27 sections
Carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 0093-0778 TABLET, CHEWABLE 100 mg ORAL ANDA 27 sections
Carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 0093-0778 TABLET, CHEWABLE 100 mg ORAL ANDA 27 sections
Carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 0121-0862 SUSPENSION 100 mg ORAL ANDA 28 sections
Carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 0121-0947 SUSPENSION 100 mg ORAL ANDA 29 sections
Carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 0121-0947 SUSPENSION 100 mg ORAL ANDA 29 sections
Carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 0121-1724 SUSPENSION 200 mg ORAL ANDA 28 sections
Carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 0121-1894 SUSPENSION 200 mg ORAL ANDA 29 sections
Carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 0121-1894 SUSPENSION 200 mg ORAL ANDA 29 sections
Carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 0615-3505 TABLET 200 mg ORAL ANDA 21 sections
CARBAMAZEPINE HUMAN PRESCRIPTION DRUG LABEL 1 0615-4515 TABLET 100 mg ORAL ANDA 25 sections
Carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8125 TABLET, CHEWABLE 100 mg ORAL ANDA 29 sections